摘要
目的:测定本院3种品牌奥美拉唑肠溶胶囊的含量、耐酸度和释放度,观察其存在的差异、为本院临床合理用药及医院药品引进提供参考。方法:使用高效液相色谱法(HPLC)对3种品牌的奥美拉唑肠溶胶囊的含量、耐酸度和释放度进行测定,通过方差分析及t检验等统计学方法对结果进行验证。结果:国产与进口奥美拉唑肠溶胶囊含量、释放度和耐酸度均符合规定,但国产与进口奥美拉唑的释放度和耐酸度差异有统计学意义(P<0.05)。结论:国产与进口奥美拉唑肠溶胶囊的释放度和耐酸度具有差异性。
Objective：To measure the content, acid-resistant degree and release rate of the 3 brands of Omeprazole enteric-coated capsuLes in our hospital, and to determine the differences among them, providing reference for clinical rational drug use and introduction of hospital drugs. Methods： Using high-performance liquid chromatography （ HPLC） to determine the content,acid-resistant degree and release rate of the 3 brands of Omeprazole enteric-coated capsuLes, and the findings were verified by statistical methods, such as analysis of variance and t-test. ResuLts： The content, acid-resistant degree and release rate of the domestic and imported Omeprazole enteric-coated capsuLes were in compliance with the required standard. However, there were significant differences in the release rate and acid-resistant degree between the domestic and imported Omeprazole enteric-coated capsuLes （P〈0.05）. Conclusion： There are differences in the release rate acid-resistant degree between the domestic and imported Omeprazole enteric-coated capsuLes.
出处
《广州医科大学学报》
2016年第2期84-86,共3页
Academic Journal of Guangzhou Medical University
关键词
奥美拉唑
肠溶胶囊
高效液相色谱法
Omeprazole
enteric-coated capsuLes
high-performance liquid chromatography
