摘要
目的探讨血红蛋白与代谢综合征（metabolic syndrome,Met S）及其组分（肥胖、血压、血糖、血脂）的关联性。方法选取来自北京电力医院和北京小汤山医院的体检者为研究对象,采用多因素Logistic回归分析Met S发病风险随基线血红蛋白（hemoglobin,Hb）浓度的变化。结果 Met S 5年发病率为14.52%,Met S组基线Hb[（144.46±13.47）g/L]明显高于未患Met S组[（141.00±14.70）g/L],差异有统计学意义（t=-5.49,P〈0.001）。多因素Logistic回归分析显示,在调整了年龄、性别后,Hb的升高与Met S发病风险的增加呈正相关。以最低四分位数作参照,随Hb升高,比值比（odds ratio,OR）值分别为1.238（95%CI：0.963~1.591）、1.243（95%CI：0.965~1.602）、1.439（95%CI：1.113~1.859）。结论 Hb与Met S及其组分存在相关性,可作为Met S发病的一个预测指标。
Objective To explore the association between hemoglobin（ Hb） and metabolic syndrome（ Met S）. Methods A total of3773 individuals in Beijing Tongren Hospital,Dianli Hospital and Xiaotangshan Hospital from 2007 to 2012 were recruited in the study.The subjects were divided into four quartiles according to Hb. Multivariate logistic regression was applied for data analysis. Results There were 2 509 males（ average 47. 94±15. 41 years old） and 1 264 females（ average 46. 63±12. 90 years old）. Five-year accumulated incidence of Met S was 14. 52%. The average baseline Hb was significantly higher in the subjects with Met S [（ 144. 46 ± 13. 47） g / L]than those without Met S [（ 141. 00 ± 14. 70） g / L]（ t =- 5. 49,P〈0. 001）. Multivariate Logistic regression analysis revealed that after adjustment of age and sex,elevated baseline Hb was positively correlated to the higher risk of Met S. Compared with individuals with lowest Hb,subjects with highest Hb were more vulnerable to Met S（ OR = 1. 439,95% CI： 1. 113- 1. 859）. Conclusion Hb is closely correlated with Met S and its components,and it can be used as a predictor of Met S.
出处
《首都医科大学学报》
CAS
北大核心
2016年第4期509-512,共4页
Journal of Capital Medical University
基金
国家自然科学基金(81530087
81373099)
北京市自然科学基金(7131002)~~
关键词
血红蛋白
代谢综合征
肥胖
血压
血脂
hemoglobin
metabolic syndrome
obesity
blood pressure
lipids
