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伏立康唑在不同人群个体化给药方案研究现状 被引量:14

Current status of research on individualized dosing regimen of voriconazole in different patient populations
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摘要 伏立康唑(voriconazole)属于第二代三唑类抗真菌药物,具有抗菌谱广、抗菌效力强的特点,尤其对于侵袭性曲霉、氟康唑耐药的念珠菌[1](如克柔念珠菌等)所致感染疗效好。加之良好的经济学特点[2],目前伏立康唑已经成为血液系统疾病[3]、免疫功能低下[4]、器官移植[5]患者治疗或预防用药的首选。一项多中心的观察性研究[6]发现,在多种抗真菌治疗方案中,
出处 《中国感染与化疗杂志》 CAS CSCD 北大核心 2016年第1期99-103,共5页 Chinese Journal of Infection and Chemotherapy
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  • 2AL-BADR1YEH D, HENG SC, NEOH CF, et al. Pharmacoeconomics of vorieonazole in the management ofinvasive fungal infections[J]. Expert Rev Pharmacoecon Outcomes Res, 2010, 10 ( 6 ) : 623-636. 被引量:1
  • 3BARRETO JN, BEACH CL, WOLF RC, et al. The incidence of invasive fungal infections in neutropenic patients with acute leukemia and myelodysplastic syndromes receiving primary antifungal prophylaxis with voriconazole[J]. Am J Hematol, 2013, 88 (4) : 283-288. 被引量:1
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  • 5KLONT RR, EGG1NK CA, RIJS A J, et al. Successful treatment of Fusarium keratitis with cornea transplantation and topical and systemic voriconazole[J]. Clin Infect Dis, 2005, 40 ( 12 ) : ell0-ell2. 被引量:1
  • 6JACOBS F, SELLESLAG D, AOUN M, et al. An observational efficacy and safety analysis of the treatment of acute invasive aspergillosis using voriconazole[J]. Eur J Clin Microbiol Infect Dis, 2012, 31 (6): 1173-1179. 被引量:1
  • 7GEIST M J, EGERER G, BURHENNE J, et al. Steady-state pharmacokinetics and metabolism of voriconazole in patients [J]. JAntimicrob Chemother, 2013, 68 ( 11 ) : 2592-2599. 被引量:1
  • 8DOLTON M J, RAY JE, CHEN SC, et al. Multicenter study of voriconazole pharmacokinetics and therapeutic drug monitoring [J]. Antimicrob Agents Chemother, 2012, 56 ( 9 ) : 4793- 4799. 被引量:1
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  • 10PARK WB, KIM NH, K/M K/-/, et al. The effect of therapeutic drug monitoring on safety and efficacy of voriconazole in invasive fimgal infections : a randomized controlled trial[J]. Clin Infect Dis, 2012, 55 ( 8 ) : 1080-1087. 被引量:1

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