摘要
目的观察微波消融术联合化疗夹心模式治疗直结肠癌术后肝转移癌的疗效。方法将直结肠癌术后肝转移癌无外科手术指征(或拒绝外科手术)的患者42例随机分为实验组和对照组。实验组:化疗+微波消融术+化疗(化疗方案:伊立替康+5-FU,次选择方案:奥沙利铂+5-FU,共完成8个周期);对照组:单纯化疗(化疗方案:伊立替康+5-FU,次选择方案:奥沙利铂+5-FU,共完成10个周期)。结果实验组和对照组治疗结束时完全缓解率分别为57.14%(12/21)和23.81%(5/21),部分缓解率分别为23.81%(5/21)和28.57%(6/21),稳定率分别为4.76%(1/21)和28.57%(6/21),有效率分别为80.95%(17/21)和52.38%(11/21),两组相比差异均有统计学意义(P<0.05),CEA、CA19-9转阴率实验组为71.43%(15/21),61.9%(13/21),对照组38.1%(8/21)、23.81%(5/21),两组相比差异均有统计学意义(P<0.05),实验组较对照组无进展生存时间平均延长5.9个月,3/4度骨髓抑制发生率实验组为19.04%(4/21),对照组治疗47.62%(10/21)。结论微波消融术联合化疗夹心模式治疗直结肠癌术后肝转移癌安全可靠、疗效确切,值得临床推广。
Objective To observe the microwave ablation combined with sandwich chemotherapy in the treatment of colorectal cancer,the efficacy of liver metastases after surgery. Methods The colorectal cancer patients with liver metastasis carcinoma with-out surgical indications （or refuse surgery） of 42 patients were randomly divided into experimental and control groups. Experimental group：chemotherapy plus microwave ablation plus chemotherapy （chemotherapy：Irinotecan＋5-FU,second option：Oxaliplatin＋5-FU,completed a total of 8 cycles） in the control group：chemotherapy （chemotherapy：Irinotecan＋5-FU,second option：Oxaliplatin＋5-FU,completed a total of 10 cycles）. Results At the end of the experimental group and the control group,complete remission rate was 57.14%（12/21） and 23.81%（5/21）,respectively,partial remission rate was 23.81%（5/21） and 28.57%（6/21）,respectively, stable rate of 4.76%（1/21） and 28.57%（6/21） respectively,the effective rate was 80.95%（17/21） and 52.38%（11/21） respectively, compared to the two groups were statistically significant differences（P〈0.05）,CEA,CA19-9 negative rate in the experimental group was 71.43%（15/21）,61.9%（13/21） in the control group,38.1%（8/21）,23.81%（5/21） the two groups were statistically significant dif-ference compared （P〈0.05）,the experimental group than the control group progression-free survival 5.9 months longer,on average, 3/4 myelosuppression incidence of experimental group was 19.04%（4/21）,the control group 47.62%（10/21）. Conclusion Mi-crowave ablation combined with sandwich chemotherapy for colorectal cancer liver metastases after surgery safe ,reliable and ef-fective,worthy of promotion.
出处
《江西医药》
CAS
2016年第8期749-752,共4页
Jiangxi Medical Journal
关键词
微波消融术
直结肠癌
肝转移癌
夹心化疗模式
Microwave ablation
Colorectal cancer
Liver metastases
Sandwich chemotherapy
