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长链非编码RNA DANCR促滑膜间充质干细胞向软骨细胞分化作用的研究进展 被引量：6

Review on long non-coding RNA DANCR enhances chondrogenic differentiation and proliferation of human synovium-derived mesenchymal stem cell
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摘要 长链非编码RNA(long non-coding RNA,lncRNA)是一类转录本长度大于200 nt,不具有翻译成蛋白质能力的RNA。lncRNA DANCR是一种近年来在肝细胞癌中发现的特异性高表达的长链非编码RNA,具有高度调控细胞分化的作用。最新研究表明,lncRNA DANCR在关节软骨损伤修复中也起着重要的调控作用,并有望成为促进滑膜间充质干细胞(synovium-derived mesenchymal stem cells,SMSCs)向软骨细胞增殖和分化的关键调控位点。文中就近年来DANCR促进SMSCs向软骨细胞增殖和分化过程中的作用及未来可能的研究热点进行综述。 Long non-coding RNA（LncRNA） is an RNA molecule that is longer than 200 nucleotides and is not translated into a protein. LncRNA DANCR has been identified in hepatoeellular carcinoma （HCC） and markedly increased sternness features of HCC cells to promote tumorigenesis. Recent studies show that DANCR contributes to the differentiation and proliferation of synovium-derived mesenehymal stem cell （SMSCs） and may be as a key point for this process. This article reviews the role of long non-coding RNA DANCR in enhancing ehondrogenic differentiation and proliferation of human SMSCs.
作者 杨超 张雷 周利武 赵建宁
机构地区 南京大学医学院附属金陵医院(南京军区南京总医院)骨科
出处 《医学研究生学报》 CAS 北大核心 2016年第8期892-896,共5页 Journal of Medical Postgraduates
基金 江苏省临床医学科技专项资助(BL2012002) 中国博士后科学基金(2016M592956)
关键词 长链非编码RNA DANCR 滑膜间充质干细胞 Long non-coding RNA DANCR Synovium-derived mesenchymal stem cells
分类号 R329.2 [医药卫生—人体解剖和组织胚胎学]
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参考文献32

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二级参考文献58

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医学研究生学报
2016年 第8期

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