摘要
目的比较拉坦前列素、曲伏前列素及噻吗洛尔滴眼液治疗原发性开角型青光眼(POAG)的效果。方法将收治的120例患者随机分为A、B、C组,每组均为40例,其中A组患者给予拉坦前列素滴眼液;B组患者给予曲伏前列素滴眼液;C组患者给予马来酸噻吗洛尔滴眼液,A、B组均为每天晚上约20:00给药1次,每次1滴,疗程为4周,C组为每天早上约08:00给药1次,每次1滴,疗程为4周。结果三组患者治疗前比较,眼压无统计学差异(P>0.05),三组患者用药治疗4周眼压值均有显著下降,用药前后差异具有统计学意义(P<0.05);拉坦前列素和曲伏前列素两种滴眼液组间治疗无显著性差异(P>0.05),但与噻吗洛尔治疗分别进行组间效果比对具有显著性差异(P<0.05)。结论拉坦前列素、曲伏前列素及噻吗洛尔滴眼液治疗POAG在一个疗程内(4周)均能有效降低眼压,疗效持久,且两种前列素降眼压作用明显优于噻吗洛尔滴眼液治疗效果。
Objectives To compare the effect of latanoprost,travoprost and timolol in primary open angle glaucoma（ POAG） patients. Methods 120 patients with POAG were randomly divided into 3 groups,with 40 cases in each group. Group A,group B and group C were treated once daily with latanoprost,travoprost and timolol eyedrops respectively,and a drop was given at 8 PM every night for every time in four weeks. Results There was no difference of intraocular pressure（ IOP） before the treatment among the three groups（ P〈0. 05）,but IOP became lower among the three groups 4weeks after the treatment,the differences were statistically significant（ P〈0. 05）. The mean IOP reducation were significantly differernt among the groups,specifically,the latanoprost group and travoprost group in comparison to the timolol group at week 4（ P〈0. 05）. Conclusions Latanoprost,travoprost and timolol eyedrops are all effective and hosting in reducing IOP in POAG,but the curative effect of latanoprost and travoprost eyedrops are better than timolol eyedrops.
出处
《临床眼科杂志》
2016年第4期315-317,共3页
Journal of Clinical Ophthalmology
