期刊文献+

聚乙二醇干扰素联合利巴韦林治疗基因1b型慢性丙型肝炎的疗效观察 被引量:5

下载PDF
导出
摘要 目的评价聚乙二醇干扰素联合利巴韦林治疗慢性丙型肝炎的临床疗效。方法使用聚乙二醇干扰素α-2a(派罗欣)联合利巴韦林治疗80例基因1b型CHC患者,疗程48周,随访24周,评价疗效及观察药物不良反应。结果获得快速病毒学应答(RVR),完全早期病毒学应答(CEVR),治疗结束时病毒学应答(ETVR)和持续病毒学应答(SVR)比例分别为65.0%,82.5%,90%,82.5%。结论聚乙二醇干扰素联合利巴韦林治疗基因1b型CHC疗效良好;治疗中不良反应普遍能耐受。
出处 《中国医药指南》 2016年第20期54-55,共2页 Guide of China Medicine
  • 相关文献

参考文献7

  • 1Mata M,Kanda T,Yu M,et al.APASL consensus statements and management algorithms for hepatitis C virus infection[J].Intern Hepatology,2012,6(2):409. 被引量:1
  • 2丙型肝炎防治指南[J].临床肝胆病杂志,2004,20(4):197-203. 被引量:735
  • 3European Association for the Study of the Liver.EASL Clinical Practice Guidelines:Management of hepatitis C virus infection[J].J Hepatol,2014,60(2):392-420. 被引量:1
  • 4Huang CF,Chuang WL.Ch ronic hepatitis C infection in the elderly[J].Kaohsiung J Med Sci,2011,27(10):533-537. 被引量:1
  • 5徐严,斯庆图娜拉,郎轶宣,张永贵,焦健,季尚玮,赵平,郭宏华,李岩,周长玉,王江滨.聚乙二醇干扰素α-2a个体化抗病毒治疗慢性丙型肝炎的疗效[J].中华传染病杂志,2012,30(3):165-169. 被引量:12
  • 6Ge D,Fellay J,Thompson AL,et al.Genetic variation in IL28B predicts hepatitis C treatment-induced viral Clearance[J].Nature,2009,461(7262):399-401. 被引量:1
  • 7Thomas DL,Thio CL,Martin MP,et al.Genetic variation in IL28B and spontaneous clearance of hepatitis C virus[J].Nature,2009,461(7265):798-801. 被引量:1

二级参考文献30

  • 1焦健,王江滨.中国东北丙型肝炎病毒感染基因特征及人群易感性分析[J].临床肝胆病杂志,2005,21(2):68-70. 被引量:5
  • 2Camma C, Bruno S, Schepis F, et al. Retreatment with interferon plus ribavirin of chronic hepatitis C non- responders to interferon monotherapy: a meta- analysis of individual patient data[ J ]. Gut, 2002,51:864-869. 被引量:1
  • 3Papatheodoridis GV, Papadimitropoulos VC, Hsdziyannis SJ. Effect of interferon therapy on the development of hepatocellular carcinoma in patients with hepatitis C virus- reated cirrhosis: a meta- analysis[J] .Aliment Pnarmaool Ther, 2001,15:689- 698. 被引量:1
  • 4Kjaergard LL, Krogsgaard K, Gluud C. Interfern alfa with or without ribavirin for chronic hepatitis C: systematic review of randonmised trials[J].BMJ, 2001,323:1151 - 1155. 被引量:1
  • 5Alberti A, Benvegnu L. Management of hepatitis[J] .J Hepatol, 2003,38(Suppl1): S1014 - S1 18. 被引量:1
  • 6Poynard T, MdHutchison J, Davis GL, et al. Impact of interferon alfa - 2b and ribavirin on progression of liver fibrosiis in patients with chronic hepatitis C[J].Hepatology, 2000,32:1131 - 1137. 被引量:1
  • 7Booth JCL, O' Grady J, Neuberger J. Clinical guidelines on the mangement of hepatitis C[J]. Gut, 2001, 49(Suppl I ): il - i12. 被引量:1
  • 8Chander G, Sulkowski MS, Jenckes MW, et al. Treatment of chronic hepatitis C: a systemic review[J]. Hepatology, 2002, 36(5 Suppl 1 ):S135 - S144. 被引量:1
  • 9Di Ciomm no V, Russo P, Rava L, etal. Interferon alpha in the treatment of chronic hepatitis C in children: a mmeta- analysis[J] .J Viral Hepat,2003,10:210 - 214. 被引量:1
  • 10Fabrizi F, Dulai G, DixitV, et al. Meta- analysis: interfeorn for the treatment of chronic hepatitis C in dialysis patients[J] .Aliment Phamacol Ther, 2003,18:1071 - 1081. 被引量:1

共引文献744

同被引文献43

引证文献5

二级引证文献6

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部