摘要
目的观察前列地尔联合单硝酸异山梨酯对不稳定型心绞痛患者的临床疗效。方法将100例不稳定型心绞痛患者随机分为对照组50例和试验组50例。对照组给予吸氧、强心、利尿、扩血管等常规基础治疗;试验组在对照组的基础上,静脉滴注硝酸异山梨酯60 mg,加入5%葡萄糖250 m L中,每天1次;静脉滴注前列地尔脂微球注射液10μg,加入0.9%Na Cl 10 m L中,每天1次。2组疗程均为14 d。出院1个月后进行十二导联24 h动态心电图检查。观察2组患者的临床疗效,通过24 h动态心电图观察缺血次数、缺血时间、心肌缺血总负荷(TIB)。结果治疗后,试验组的总有效率为90.00%(45/50例),对照组为74.00%(37/50例,P<0.05)。试验组24 h内的缺血次数为(4.60±0.80)次,总缺血时间为(20.20±5.10)min,心肌缺血总负荷为(1.90±0.80)min·m V^(-1);对照组24 h内的缺血次数为(6.40±1.40)次,总缺血时间为(30.30±5.00)min,心肌缺血总负荷为(2.70±0.80)min·m V^(-1)(均P<0.05)。试验组治疗对心肌缺血总负荷的有效率为86.00%(43/50例),对照组为60.00%(30/50例,P<0.05)。2组均无明显的药物不良反应发生。结论前列地尔联合硝酸异山梨酯治疗不稳定型心绞痛临床疗效显著,可减轻心绞痛症状,改善心肌缺血总负荷。
Objective To investigate the clinical effect of alprostadil combined with isosorbide mononitrate on patients with unstable angina pectoris. Methods A total of 100 patients with unstable angina pectoris were randomly divided into control group and treatment group, 50 cases in each group. Patients in control group were treated with conventional symptomatic and supportive treatment such as oxygen, strong heart, diu- retic and vasodilator. Patients in treatment group were given intravenous infusion of alprostadil （60 rag added into 5% glucose injection 250 mL, qd） and nitrate isosorbide esters （ 10 ~g added into 0. 9% NaCl 10 mL, qd）. The course of treatment was 14 d. After discharge for 1 month, the 24 h dynamic electrocardiogram was evaluated. The clinical efficacy was evaluated before and after treatment. The number of ischemia, the time of ischemia, and the total load of myocardial ischemia （TIB） were observed by 24 h dynamic electrocardiogram （ECG）. Results The clinical effect in treatment group was 90. 00% （45/50）, had significant difference with 74. 00% （ 37/50 ） in control group （ P 〈 0. 05 ） . Thenumber of ischemia time, total ischemia time, total load of myocardial ischemia in treatment group were （4.60 ±0. 80）, （20. 20 ±5.10） rain, （ 1.90 ±0. 80） min · mV^-1 , had significant difference with （6. 40 ± 1.40）, （30. 30 ± 5.00） rain, （2.70 ± 0. 80） min · mV^ - 1 in control group （ P 〈 0.05 ）. The effect on total load of myocardial ischemia in treatment group was 86. 00% （43/50）, had significant difference with 60. 00% （30/50） in control group （P 〈 0. 05 ）. There were no significant adverse drug reactions in two groups. Conclusion Alprostadil combined with isosorbide mononitrate had good chnical efficacy in the treatment of unstable angina pectoris, which can alleviate the symptoms of angina and improve total ischemia burden.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2016年第15期1356-1358,共3页
The Chinese Journal of Clinical Pharmacology
