摘要
宫颈癌是妇科最常见的恶性肿瘤,而恶性肿瘤的发生、发展常与免疫抑制有关。在肿瘤免疫中,T细胞免疫应答发挥关键作用。T细胞活化的第2条信号通路需要共刺激因子与其受体相结合。缺乏第二信号共刺激因子,第1条信号通路形成的抗原复合物会导致T细胞失活或功能紊乱。B7家族是近年针对共刺激因子的研究热点,可对T细胞免疫应答起正性和(或)负性调节作用。综述负性共刺激因子B7-H4在宫颈癌患者血液和组织中的表达及意义,探讨其在宫颈癌研究中存在的问题;简要介绍B7-H4在卵巢癌患者血液和组织中的表达及意义。同时对B7-H4提示预后、辅助诊断及免疫治疗等进行展望,旨在进一步阐明宫颈癌免疫抑制机制,进一步探索有效的免疫靶向治疗手段。
Cervical cancer is the most common tumor in gynecologic oncology,and the generation and progression oftumor is always associated with immunosuppression. In tumour immunity, T cell-mediated immune response plays a key role.The second signal pathway in T cell activation requires the combination of costimulatory and its receptors. Lacking of the secondsignal of costimulatory, antigen complexes formed in the first signal pathway can lead to inactivation or dysfunction of T cells. Inrecent years, B7 family has become an intense focus of research in costimulatory molecules,and can play a positive and/ornegative regulatory role in T cell-mediated immune response. This paper is aimed to review the expression and significance ofnegative costimulatory molecule B7-H4 in the blood and tissues of patients with cervical cancer, and to discuss the problems inthe study of cervical cancer, and to introduce briefly the expression and significance in ovarian cancer, as well as to prospect theprognosis,the help of auxiliary diagnosis and immunization therapy. Also it is aimed to further clarify the mechanism ofimmunosuppression of cervical cancer, and further explore the effective methods of immune targeted treatment.
出处
《国际妇产科学杂志》
CAS
2016年第4期432-435,共4页
Journal of International Obstetrics and Gynecology
基金
盛京自由研究者计划(201302)
