摘要
目的:分析急性冠状动脉综合征(ACS)患者合并糖耐量异常对D-二聚体(DD)含量的影响。方法:选择135例住院治疗的ACS患者。根据糖代谢情况,患者被分为单纯ACS组(48例),2型糖尿病(T2DM)+ACS组(46例)和糖耐量减低(IGT)+ACS组(41例);同期住院健康体检者35例作为正常对照组。测定比较各组的血浆DD水平。结果:与正常对照组和单纯ACS组比较,T2DM+ACS组和IGT+ACS组的甘油三酯水平[(1.12±0.39)mmol/L,(1.52±0.92)mmol/L比(2.57±1.17)mmol/L,(2.32±0.96)mmol/L]显著升高(P均<0.01);与正常对照组比较,单纯ACS组、T2DM+ACS组和IGT+ACS组患者血浆DD水平[(360.50±74.95)ng/ml比(795.24±134.10)ng/ml比(663.31±116.06)ng/ml,(702.40±126.64)ng/ml]均显著升高(P均<0.01);而T2DM+ACS组和IGT+ACS组的血浆DD水平显著低于单纯ACS组(P均<0.05)。结论:急性冠状动脉综合征合并糖耐量减低患者纤溶系统功能较单纯ACS患者减退。
Objective： To analyze influence of acute coronary syndrome （ACS） complicated abnormal glucose metabo-lism on D-dimer （DD） content. Methods： A total of 135 ACS inpatients were selected. According to glucose metabo-lism status, they were divided into pure ACS group （n=48）, type 2 diabetes mellitus （T2DM） ＋ ACS group （n = 46） and impaired glucose tolerance （IGT） ＋ ACS group （n=41） ; another 35 subjects hospitalized and undergoing physical examination during the same period were enrolled as normal control group. Plamsa DD levels were meas-ured and compared among all groups. Results： Compared with normal control group and pure ACS group, there were significant rise in triglyceride level [ （1. 12 =h 0. 39） mmol/L,（1. 52 = 0. 92） mmol/L vs. （2. 57 ± 1.17） mmol/L, （2. 32±0. 96） mmol/L] in T2DM＋ACS group and IGT＋ACS group,P〈0. 01 all; compared with normal control group, there were significant rise in plasma DD level in pure ACS group, T2DM＋ACS group and IGT＋ACS group [（360. 50±74. 95） ng/ml vs. （795. 24±134. 10） ng/ml vs. （663. 31±116. 06） ng/ml,（ 702. 40±126. 64） n g /m l ]P 〈0. 01 all,and those of T2DM＋ACS group and IGT ＋ ACS group were significantly lower than that of pure ACS group,P〈0. 05 both. Conclusion： Fibrinolytic system function of patients with ACS impaired glucose tolerance is significantly lower than that of pure ACS patients.
出处
《心血管康复医学杂志》
CAS
2016年第4期345-348,共4页
Chinese Journal of Cardiovascular Rehabilitation Medicine
基金
国家自然科学基金(81570297)~~
关键词
糖尿病
2型
葡萄糖代谢障碍
急性冠状动脉综合征
Diabetes mellitus, type 2
Glucose metabolism disorders
Acute coronary syndrome
