摘要
目的：观察厄贝沙坦与苯磺酸氨氯地平治疗原发性高血压前后血压变化情况，探讨厄贝沙坦与苯磺酸氨氯地平对血压及血压变异性（BPV）影响。方法将入选的高血压患者119例按年龄、性别、血压、左室重量指数随机分为 A 组60例（厄贝沙坦组），B 组59例（苯磺酸氨氯地平组）。随访观察第24周后分别检查以下指标：肝肾功，空腹血糖、总胆固醇、低密度脂蛋白、24 h 收缩压血压变异系数（24 h SCV）、日间收缩压变异系数（dSCV）、夜间收缩压变异指数（nSCV）、24 h 舒张压变异系数（24 h DCV）、日间舒张压变异系数（dDCV）、夜间舒张压变异系数（nDCV）、左室重量指数（LVMI）、尿微量白蛋白、颈动脉内膜中层厚度（IMT）。结果治疗后 A、B 组24 h SCV、dSCV、nSCV 均较治疗前明显降低，差异有统计学意义（A 组治疗后收缩压变异性与治疗前比较通过配对 t 检验：24 h SCV t ＝4．42；dSCV t ＝3．46；nSCV t ＝4．7，P ＜0．01。B 组治疗后收缩压变异性与治疗前比较配对 t 检验：24 h SCV t ＝3．93；dSCV t ＝2．38；nSCV t ＝5．00，均 P ＜0．01）；A 组较 B 组下降更明显，两组比较差异有统计学意义（B 组治疗后收缩压变异性与 A 组治疗后组间比较两样本 t 检验：24 h SCV t ＝3．16；dSCV t ＝2．95；nSCV t ＝2．26，均 P ＜0．05）。治疗后 A、B 组24 h DCV、dDCV、nDCV 均较治疗前明显降低，差异有统计学意义（A 组治疗后舒张压变异性与治疗前比较通过配对 t 检验：24 h DCV t ＝9．96；dDCV t ＝3．31；nDCV t ＝5．93，均 P ＜0．01；B 组治疗后舒张压变异性与治疗前比较配对 t 检验：24 h DCV t ＝5．38；dDCV t ＝2．19；nDCV t ＝5．76，均 P ＜0．01）。A 组较 B 组下降更明显，两组比较差异有统计学意义（B 组治疗后舒张压变异性与 A 组治疗后组间比较两样本 t 检验：24 hDCV t ＝2．42；dDCV t �
Objective To study the effects of irbesartan and amlodipine on blood pressure variability （BPV） by observation of irbesartan and amlodipine in treatment of essential hypertension before and after the change of blood pressure.Methods 119 hypertensive patients were randomly divided into group A and group B according to age,sex, blood pressure,left ventricular mass index.60 patients were treated with irbesartan （group A）,and another 59 patients were treated with amlodipine（group B）.Liver and kidney function,blood glucose,cholesterol,low density lipoprotein,24h systolic blood pressure variation coefficient （24SCV）,coefficient of variation of daytime systolic （dSCV）,night systolic blood pressure variability index （nSCV）,24h diastolic blood pressure coefficient of variation （24DCV）,day-time diastolic blood pressure variability （dDCV）,nocturnal diastolic blood pressure variation coefficient （nDCV）,left ventricular mass index （LVMI）,urine micro albumin,carotid intima -media thickness （IMT）level were examined at the 24th week of the therapy.Results （1 ）The levels of 24h SCV,dSCV,nSCV after treatment were significantly lower than before treatment both in group A and group B （group A：24hSCV t =4.42;dSCV t =3.46;nSCV t =4.70, group B：24hSCV t =3.93;dSCV t =2.38;nSCV t =5.00,all P 〈0.01）.Comparison of BPV between group A and group B after treatment,the 24hSCV,dSCV,nSCV of group A were lower than those of group B（24hSCV t =3.16;dSCV t =2.95,;nSCV t =2.26,all P 〈0.05）.（2）The levels of 24hDCV,dDCV,nDCV after treatment were signifi-cantly lower than before treatment both in group A and group B（group A：24hDCV t =9.96;dDCV t =3.31;nDCV t =5.93,all P 〈0.01;group B：24hDCV t =5.38;dDCV t =2.19;nDCV t =5.76,all P 〈0.01）.Comparison of BPV between group A and group B after treatment,24hDCV,dDCV,nDCV of group A were lower than those of group B （24hDCV t =2.42;dDCV t =1.44;nDCV t =2.45,all P 〈0.05）.（3）The level of LVMI after treatment was signifi-cant
出处
《中国基层医药》
CAS
2016年第16期2476-2481,共6页
Chinese Journal of Primary Medicine and Pharmacy
