摘要
目的探讨血清心型脂肪酸结合蛋白(heart fatty acid binding protein,H-FABP)在急性脑梗死(acute ischemic stroke,AIS)和脑出血(intracerebral hemorrhage,ICH)患者中的表达差异,分析其与病理特征间的关系。方法发病12h内AIS患者89例(AIS组)和ICH患者66例(ICH组),采用双抗体夹心ELISA法检测2组血清H-FABP水平,分析血清H-FABP水平与梗死部位、梗死灶大小和梗死病因分型间的关系。结果AIS组血清H-FABP水平[132.14(81.63,324.26)ng/L]与ICH组[171.35(102.86,382.65)ng/L]比较差异无统计学意义(P>0.05);AIS组和ICH组血清H-FABP水平与初始NIHSS评分均无明显相关性(r=-0.110,P=0.307;r=0.094,P=0.451);AIS组血清H-FABP水平在梗死灶大小和梗死部位上差异无统计学意义(P>0.05);心源性脑梗死患者血清H-FABP水平[263.65(126.32,627.17)ng/L]高于动脉硬化性脑梗死[115.36(82.14,232.48)ng/L]、小血管性梗死[123.06(74.95,288.82)ng/L]和其他病因梗死患者[130.43(59.88,268.10)ng/L](P<0.05)。结论血清H-FABP水平不能鉴别AIS和ICH,可能是预测心源性脑梗死的潜在分子标志物。
Objective To explore the difference of serum heart fatty acid binding protein （H-FABP） in patients with acute isehemic stroke （AIS） and acute intracerebral hemorrhage （ICH）, and to analyze its relationship with the pathological features. Methods The serum H FABP levels were detected by ELISA in 89 patients with AIS （AIS group） and 66 patients with ICH （ICH group） within 12 hours after onset. The relationships of serum H-FABP with infarct site, size and causes were analyzed. Results There was no significant difference in serum H-FABP level between AIS group （132.14（81.63, 324.26） ng/L） and ICH group （171.35（102.86, 382.65） ng/L） （P〉0.05）. SerumH FABPlevelwas not obviously correlated with initial NIHSS score either in AIS group （r=-0. 110, P=0. 307） or in ICH group （r= 0. 094, P=0. 451）. There were no significant differences in the serum H FABP levels in different infarct sizes and sites in AIS group （P〉 0.05）. The serum H-FABP level was significantly higher in patients with cardiac cerebral infarction （263.65（126.32, 627.17） ng/L） than that in patients with atherosclerotic cerebral infarction （115.36 （82.14, 232.48） ng/L）, small vascular infarction （123.06 （74.95, 288.82） ng/L） and other infarctions （130.43（59.88, 268.10） ng/L） （P〈0.05）. Conclusion Serum H-FABP can not be used in the differential diagnosis of AIS and ICH, but it may be a potential biomarker for predicting cardiac cerebral infarction.
出处
《中华实用诊断与治疗杂志》
2016年第8期777-779,共3页
Journal of Chinese Practical Diagnosis and Therapy
基金
河南省重点科技攻关计划项目(122102310138)
河南省国际合作计划项目(134300510015)
关键词
急性脑梗死
脑出血
心型脂肪酸性结合蛋白
Acute ischemic stroke
intracerebral hemorrhage
heart fatty acid binding protein
