摘要
氧化应激与人体健康密切相关,而黄酮类化合物因能激活人体内调节众多抗氧化基因表达的关键性防御通道——Nrf2-ARE信号通道,对抗氧化应激有着十分显著的作用。文章介绍了Nrf2-ARE信号通道的激活、调控Nrf2-ARE激活的相关信号通路、受Nrf2-ARE调控的下游基因以及Nrf2-ARE介导的黄酮类化合物对炎症和凋亡反应的影响,同时对Nrf2-ARE介导的八大类主要黄酮化合物在抗氧化应激方面的研究进行综述,并提出现阶段研究存在的主要科学问题及解决策略,以期为黄酮类化合物在预防和治疗氧化应激相关性疾病等领域的研究提供参考。
Oxidative stress has very close relationship with human health,and human organsviolated by oxidative stress is likely to cause a series of physical diseases,such as headache,muscle aches,arthritis,atherosclerosis,diabetes,heart disease,cancer and neurodegenerative problem.However the flavonoids which widely exist in fruits,vegetables and other plant foods have a very significant role in the fight against oxidative stress,this is largely because it can activate the Nrf2-ARE which is the critical defense signaling pathway and regulating many antioxidant gene expression.In this paper,introduced the activation of Nrf2-ARE signaling pathway,the related signaling pathways of regulating Nrf2-ARE activation,the downstream genes regulated by Nrf2-ARE,and the influence of the Nrf2-ARE applied to inflammatory and apoptosis reaction.Meanwhile reviewed the research progress of eight kinds of flavonoids on the Nrf2-ARE signaling pathway and put forward the main scientific problems and solution strategy of the present study to provide reference for study of flavonoids in the field of prevention and treatment of oxidative stress-related diseases.
出处
《食品与机械》
CSCD
北大核心
2016年第6期201-207,共7页
Food and Machinery
基金
湖南省自然科学基金青年人才培养联合基金(编号:14JJ6067)
