摘要
目的:探讨三亚地区黎族原发性肝癌患者个体化综合治疗的疗效及预后的相关因素.方法:回顾性分析70例经个体化综合治疗的三亚地区黎族原发性肝癌患者的临床资料,全部原发性肝癌患者均为三亚地区黎族患者,采取以手术、介入栓塞化疗(transcatheter arterial chemoembolization,TACE)、分子靶向治疗、局部消融治疗以及中药扶正等综合治疗,观察个体化治疗后疗效及预后,分析相关因素.结果:70例患者中位生存期为9 mo.单因素分析结果显示:BCLC分期为0-B期、接受TACE术、接受手术、甲胎蛋白<200 ng/mL、无合并肝硬化、Child-Pugh分级为A级、有局部消融治疗和分子靶向药物治疗与预后相关有统计学意义(P<0.05).多因素分析显示:无合并肝硬化(P=0.012)、Child-Pugh分级为A级(P=0.000)、有接受手术(P=0.020)及BCLC分期为0-B期(P=0.006)为影响三亚地区黎族原发性肝癌患者综合治疗后远期疗效的保护因素.结论:三亚地区黎族原发性肝癌患者经手术、TACE、分子靶向治疗、局部消融治疗等综合治疗获得了较长的生存时间,早期发现和早期接受手术治疗以及较好的肝功能状态等综合治疗仍然为三亚地区黎族原发性肝癌患者有效的治疗模式.
AIM：To identify factors related to the efficacy of personalized comprehensive treatment and prognosis in 70 Li residents with hepatocellular carcinoma in Sanya.METHODS：The clinical data of 70 Li residents undergoing personalized comprehensive treatment for hepatocellular carcinoma were reviewed retrospectively.Surgery combined with chemotherapy,transcatheter arterial chemoembolization（TACE）,molecular targeted agents,ablation therapy,Chinese herbal medicine and others were chosen for the patients.Factors related to the efficacy of personalized comprehensive treatment and prognosis were identified by univariate and multivariate analyses.RESULTS：The median survival time of the 70 patients was 9 mo.Univariate analysis showed that BCLC stages 0-B,TACE,surgery,AFP 200 ng/mL,absence of cirrhosis,ChildPugh grade A,ablation therapy and molecular targeted treatment were significantly associated with prognosis（P0.05）.Multivariate Logistic regression analysis revealed that surgery（P=0.020）,absence of cirrhosis（P=0.012）,Child-Pugh grade A（P=0.000）,and BCLC stages 0-B（P=0.006） were independent protective factors for long-term efficacy of personalized comprehensive treatment for 70 Li residents with hepatocellular carcinoma in Sanya.CONCLUSION：Surgery combined with molecular targeted agents,TACE,ablation therapy and others prolongs survival time in Li residents with hepatocellular carcinoma in Sanya.
出处
《世界华人消化杂志》
CAS
2016年第20期3188-3194,共7页
World Chinese Journal of Digestology
基金
海南省卫生厅2013年度医学科研课题基金资助项目
No.琼卫科教[2013]64号~~
