摘要
目的探讨外周血淋巴细胞/单核细胞比值（LMR）与恶性胸膜间皮瘤（MPM）患者预后的关系。方法收集85例MPM患者的临床资料和随访资料,根据外周血LMR值将患者分为高LMR组（n=27）和低LMR组（n=58）,对比分析两组临床病理资料和生存时间,并采用Cox回归模型分析LM R及其他临床病理因素与患者总生存期的关系。结果两组性别、功能状态（PS）评分、淋巴细胞计数和单核细胞计数差异有统计学意义（P〈0.05）。高LMR组中位生存时间（27个月）显著长于低LMR组（9个月）（P〈0.001）。在不同组织学类型和肿瘤分期患者中,高LMR组中位生存时间均长于低LMR组（P〈0.05）。多因素分析显示,LMR是影响MPM患者总生存期的独立因素（HR：0.277;95%CI：0.142-0.538;P〈0.001）。结论外周血LMR可作为反映MPM患者生存预后的生物学标志物。
Objective To explore the correlation between lymphocyte-to-monocyte ratio（ LMR） in peripheral blood and prognosis of malignant pleural mesothelioma（ MPM）. Methods Clinicopathological data of 85 patients with MPMwere retrospectively analyzed. According to the LMR in peripheral blood,the patients were divided into two groups： high LMR group（ n = 27） and lowLMR group（ n = 58）. The clinicopathological data and overall survival of the two groups were compared. The correlation between the clinicopathological data and the overall survival was analyzed with Cox regression model. Results Significant differences were observed between the two groups in gender,performance status（ PS） score,absolute lymphocyte count and absolute monocyte count（ P〈0. 05）. The median overall survival of patients with high LMR was significantly longer than that of patients with lowLMR（ 27 months vs 9months,P〈0. 001）. Of patients with various histological types and tumor stages,the median overall survival of patients with high LMR was significantly longer than that of patients with lowLMR. Multivariate analysis showed that LMR was an independent prognostic factor associated with prognosis of MPM（ HR： 0. 277; 95% CI： 0. 142-0. 538;P〈0. 001）. Conclusion LMR in peripheral blood is a biological marker for the prognosis of MPM.
出处
《山东大学学报（医学版）》
CAS
北大核心
2016年第8期72-77,共6页
Journal of Shandong University:Health Sciences
基金
国家自然科学基金(81301790)
山东省重点研发计划(2015GSF118028)
关键词
淋巴细胞/单核细胞比值
恶性胸膜间皮瘤
预后
总生存期
胸腔镜
Lymphocyte-to-monocyte ratio
Malignant pleural mesothelioma
Prognosis
Overall survival
Thoracoscopy
