摘要
目的观察双歧杆菌四联活菌片联合用药方案治疗小儿非感染性腹泻的疗效,据此分析是否会对血清IL-6、IL-17炎性因子表达产生影响。方法选择2014年2月-2016年2月期间在我院儿科住院治疗的128例非感染性腹泻的患儿,按照随机原则分为两组,其中对照组常规治疗,而观察组患儿则是再辅以双歧杆菌四联活菌片治疗,对比两组患儿治疗后的疗效、治疗前后血清中IL-6和IL-17水平、腹泻停止时间以及体温恢复正常时间。结果对照组患儿总有效率为64.06%（41/64）,观察组总有效率则为87.5%（56/64）,差异显著（P〈0.05）;治疗后两组患儿的IL-6和IL-17水平均有明显的下降,比治疗前有着显著的改善（P〈0.05）,同时观察组患儿总体改善程度更有临床优势,差异显著（P〈0.05）;对照组患儿腹泻停止时间、体温正常时间分别是（4.67±0.72）d、（5.91±1.23）d,而观察组则分别是（2.35±0.58）d、（3.67±1.08）d,差异显著（P〈0.05）。结论对小儿非感染行腹泻而言,常规治疗疗效欠佳、治疗周期长,而采用了双歧杆菌四联活菌片联合治疗方案后,疗效显著提升同时缩短了治疗周期,同时患儿IL-6和IL-17水平也进一步下降,值得临床借鉴推广。
Objective To observe the efficacy of sheet of viable Bifidobacterium quadruple combination therapy to non-infectious diarrhea in children and its effects in the expression of IL-6 and IL-17. Methods 128 cases of children with non-infectious diarrhea cured in our hospital pediatric hospital from February 2014 to February 2016 were randomly divided into control group and observation group. Patients in control group were supplemented by conventional treatment. Patients in observation group were supplemented by sheet of viable Bifidobacterium quadruple treatment. The curative effects after treatment, serum levels of IL-6 and IL-17 before and after treatment, diarrhea stop time and body temperature return to normal time of the two groups were compared. Results The total effective rate of control group was 64.06%（41/64）. The total effective rate of the observation group was 87.5%（56/64）. The difference was significant（P〈0.05）. After treatment, the levels of IL-6 and IL-17 were significantly decreased in the two groups, which were significantly improved than before treatment（P〈0.05）. The stop time of diarrhea and the normal time of body temperature of control group were（4.67 ± 0.72） d and（5.91 ± 1.23） d, however, the observation group were（2.35 ± 0.58） d and（3.67 ± 1.08） d. The difference was significant（P〈0.05）. Conclusion For children with non-infectious diarrhea, conventional treatment was not good, and the treatment period was long. After using sheet of viable Bifidobacterium quadruple combination therapy, the curative effect was significantly improved and the treatment period was shortened, at the same time, the IL-6 and IL-17 levels in children were also decreased. It was worthy of clinical reference and promotion.
出处
《中国医药科学》
2016年第11期100-102,133,共4页
China Medicine And Pharmacy
