摘要
目的探讨降钙素原(PCT)在颅脑术后感染的诊断价值。方法收集52例颅内手术后细菌感染患者作为观察组,50例术后无颅内感染患者作为对照组,检测患者血清PCT、C-反应蛋白(CRP)、白细胞(WBC)计数并进行比较分析。结果观察组的PCT、CRP、WBC水平明显高于对照组,差异均有统计学意义(P<0.05)。PCT、CRP、WBC的AUC分别为0.936、0.858、0.784。PCT临界值为0.085 ng/ml作为cut-off值时,灵敏度、特异度分别为92.3%、88.0%;CRP计数临界值为9.95 mg/L时,灵敏度、特异度分别为88.5%、76.0%;WBC临界值为10×109/L时,灵敏度、特异度分别为76.9%、72.0%。结论在颅脑术后并发细菌感染的诊断中,血清PCT检测优于CRP与白细胞计数,具有较好的诊断价值、灵敏度及特异度,更值得临床推广应用。
Objective To investigate the value of serum procalcitonin （PCT） in the diagnosis of post - craniotomy intracranial infection. Methods 52 post - eraniotomy patients with intraeranial infection were selected as the observation group, with 50 without intraeranial infection as the control group. Serum PCT, CRP and white blood cell （WBC） count in the patients were compared and analyzed. Results PCT, CRP and WBC levels in the observation group were significantly higher than those in the control group, with the differences statistically significant（ P 〈 0.05 ）. The area under curve（AUC） of PCT, CRP and WBC were respectively 0.936, 0. 858 and 0.784. When the critical value of PCT was determined to be 0.085 ng/ml as the cut - off value, the sensitivity and specificity of PCT for the diagnosis the post - craniotomy intracranial infection were 92.3% and 88.0% ; when the critical value of CRP was 9.95 mg/L, the sensitivity and specificity were 88.5% and 76% respectively. The sensitivity and specificity were 76.9% and 72.0%, respectively, when the critical value of WBC was 10×109/L. Conclu, sion In the diagnosis of bacterial infection after cranioeerebral operation, the detection of serum PCT is better than CRP and WBC count, it has a good diagnostic value, sensitivity and specificity, so it is worthy of clinical application and promotion.
出处
《中国卫生检验杂志》
CAS
2016年第14期2051-2052,共2页
Chinese Journal of Health Laboratory Technology
关键词
颅内感染
降钙素原
C-反应蛋白
白细胞计数
Intracranial infection
Procalcitonin
C -reactive preotein
White blood cell count
