摘要
目的研究鼻咽癌放疗患者口腔感染的影响因素。方法回顾性分析291例鼻咽癌患者的临床资料,对其进行为期1年的随访,利用单因素和多因素分析方法进行数据统计,分析鼻咽癌放疗患者口腔感染的影响因素。结果患者住院30天后发生口腔感染,感染有113例约占38.83%,数据显示47例为真菌感染,感染菌种以白假丝酵母菌培养阳性为主有32例占68.08%,热带假丝酵母菌其次;41例为细菌培养阳性感染;25例为混合感染。咪康唑、酮康唑耐药率最高,其他病原菌耐药率都很低。单因素分析显示,癌症病期、口腔自洁、口腔p H值、口腔环境、性别、营养状况、年龄、文化程度以及是否化疗作为患者发生口腔感染的相关因素(P﹤0.05);多元Logistic分析显示,口腔环境差,癌症晚期,口腔自洁差,是否愿意化疗及年龄是本研究的危险因素。结论口腔感染受多方面综合因素影响,加强真菌感染的危险因素控制,如抗菌药物的合理应用,加强无菌操作和营养支持,控制危险因素的发生,结合病情制定有效方案。
Objective To investigate the factors influencing oral infection in patients who were treated with radiother-apy for nasopharyngeal carcinoma. Method The clinical profiles of 291 cases of nasopharyngeal cancer patients who were followed for 1 year were retrospectively analyzed, univariate and multivariate analysis were applied to investigate the factors that influence oral infection in nasopharyngeal cancer patients receiving radiotherapy. Result Oral infection developed in 113 patients （38.83%） after 30 days of hospitalization, in which 47 cases were fungal infection, with positive candida albicans culture in 32 cases （68.08%）, and some were candida tropicalis;another 41 cases were with positive in-fection of germiculture; and other 25 cases were mixed infection. Most pathogenic bacterium were resistant to micon-azole and ketoconazole, while not to the others. The univariate analysis showed that, cancer stage, oral self-cleaning, oral pH, oral environment, sex, nutritional status, age, education background and chemotherapy were related with oral infec-tion （P〈0.05）;multivariate Logistic analysis showed that poor oral environment, advanced cancer, poor oral self-cleaning, chemotherapy and age were risk factors in this study. Conclusion Oral infection is associated with multiple factors, so it is essential to strengthen the risk control of fungal infection, including the rational use of antibiotics, and to follow aseptic operation and enhance nutritional support.
出处
《癌症进展》
2016年第5期489-491,共3页
Oncology Progress
关键词
鼻咽癌
放疗
口腔感染
相关因素
nasopharyngeal carcinoma
radiotherapy
oral infection
related factors
