摘要
背景全身麻醉药应用于临床已有近170年，然而其作用的神经机制还不清楚。蓝斑去甲肾上腺素能神经系统（locus coeruleus-noradrenergic system, LC-NE）在全身麻醉状态调节中可能起到重要作用。目的综述LC-NE系统在调节全身麻醉中的研究进展。内容全身麻醉药可能通过对LC-NE系统的抑制从而产生镇静催眠效果。趋向探讨LC-NE神经系统在全身麻醉中所起到的作用，为揭示全身麻醉药的作用机制提供新思路。
Background Although general anesthetics have been used in clinic for nearly 170 years, it is still unclear how these drugs modulate the state of general anesthesia in the brain. Mounting evidence shows that the locus coeruleus （LC） noradrenergic （NE） system （LC-NE） may play an important role in the modulation of general anesthesia. Objective To review the progresses about the roles of the LC-NE system in modulating general anesthesia. Content General anesthetics may exert their sedative and hypnotic effects through inhibition of LC-NE system. Trend To provide a new view angle for the mechanism study of general anesthesia through discussing the role of the LCoNE system in general anesthesia.
出处
《国际麻醉学与复苏杂志》
CAS
2016年第7期649-652,共4页
International Journal of Anesthesiology and Resuscitation
关键词
蓝斑
去甲肾上腺素
麻醉
睡眠
Locus coeruleus
Norepinephrine
General anesthesia
Sleep
