摘要
目的探讨头孢菌素所致双硫仑样反应的致病机制,以求为临床防治提供参考。方法 2013年2月至2015年6月期间,有23例老年患者因使用头孢菌素导致双硫仑样反应而就诊于北京友谊医院,对其进行回顾性的分析。其中男性21例,女性2例,平均年龄67.4岁（60~86岁）。对患者的一般资料、临床检查、诊疗过程及转归等情况进行观察。结果首诊即诊断为双硫仑样反应者11例（47.8%）,其余12例（52.2%）均诊断为其他疾病,其中8例诊断为急性冠脉综合征,2例诊断为急性左心衰,1例为感染中毒性休克,1例诊断为过敏反应。所有患者在给予对症处理后,平均3 h左右情况均明显好转,无一例死亡病例。结论应用头孢类抗生素过程中,接触乙醇易出现双硫仑样反应,医务人员应对双硫仑样反应引起重视,尤其是有冠心病基础的患者,应用抗生素及用后1周内应避免饮酒。
Objective To explore the pathogenic mechanism of disulfiram like reaction caused by cephalosporin, in order to provide certain reference for medical prevention and cure. Methods From February 2013 to June 2015, 23 cases were admitted in Beijing Friendship Hospital for disulfiram like reaction caused by cephalosporin, including 21 male and 2 female with an average age of 67.4 years to 86 years old）. We observed the general information, clinical examination, diagnosis and treatment of the patients and so on. range from 60 Results 11 cases （47.8%） were diagnosed with disulfiram like reaction initially, the remaining 12 cases （52.2%） were diagnosed as other diseases, including 8 cases diagnosed as acute coronary syndrome, 2 cases diagnosed with acute left heart failure, 1 case of toxic shock of infection, 1 case of diagnosis of allergic reactions. After given symptomatic treatment, all patients got better in a average of 3 hours and there were no death case. Conclusion In the process of application of eephalosporins antibiotics, the contact of ethanol is easy to lead to the appearance of disulfiram like reaction, which we must pay more attention to, especially in patients with coronary heart disease （ CHD）. With application of antibiotics and alcohol, we should avoid contact untill 1 week latter.
出处
《临床和实验医学杂志》
2016年第14期1447-1449,共3页
Journal of Clinical and Experimental Medicine
基金
北京市优秀人才培养资助青年骨干个人项目(2014000021469G265)
关键词
老年人
头孢菌素
双硫仑样反应
冠心病
Elderly
Cephalosporin
Disulfiram like reaction
Coronary heart disease
