摘要
目的了解某三甲医院2013~2015年临床分离的铜绿假单胞菌分布情况,及其对常用抗菌药物敏感性的动态变化,为临床控制感染和指导临床抗感染治疗及合理用药提供实验室依据。方法采用回顾性调查分析方法,对铜陵市人民医院临床微生物室2013~2015年临床科室送检各类标本分离出的铜绿假单胞菌,应用WHONTE 5.6软件对其临床科室分布和药敏试验数据进行统计分析。结果铜绿假单胞菌的检出率呈逐年增加;标本主要来源于痰液,平均占70.49%,其次为创面伤口分泌物,平均占12.85%;主要分布在重症监护室和呼吸内科,分别为15.86%和15.63%;3年间对阿米卡星的敏感性均保持在〉90%,对头孢他啶和头孢吡肟敏感率逐年增高,至2015年,敏感率均〉80%,对头孢噻肟、头孢曲松及磺胺甲恶唑/甲氧苄啶保持耐药,耐药率均〉70%,对替卡西林/克拉维酸耐药率呈逐年下降,对亚胺培南和美罗培南的耐药率维持在30%左右。结论铜绿假单胞菌引起的感染增多,以肺部感染为主,检出率呈现逐年增加趋势,且耐药性日趋严重,应加强耐药性监测。
Objective To investigate the distribution and analysis of the antibiotic resistance of Pseudomonas aeruginosa isolated in Tongling People＇s Hospital from 2013 to 2015 for clinical infection control and clinical laboratory,so as to provide the basis for treatment of infections and rational drug use. Methods A retrospective survey analysis was made in various specimens of P. Aeruginosa isolated from clinical samples in the Clinical Microbiology Lab of Tongling People＇s Hospital from 2013 to 2015,and WHONTE5. 6 was applied in the statistical analysis of the distribution of clinical departments and experimental data of drug susceptibility tests. Results The detection rate of P. aeruginosa increased year by year,mainly from sputum specimens,with an average of 70. 49%,followed by wound wound secretion,with an average of 12. 85%. The department distribution was mainly in the intensive care unit and respiratory medicine department（ 15. 862% and15. 63% respectively）. During three year,the sensitivity to amikacin was maintained greater than 90%; that to ceftazidime and cefepime increased year by year,until 2015,the sensitivity to both was over 80%; cefotaxime,ceftriaxone and sulfamethoxazole oxazole / trimethoprim maintained resistance,and the resistance rate was both higher than 70%; ticarcillin / clavulanic acid had a certain resistance rate,which showed a certain degree of declining; the resistance to imipenem and meropenem was maintained about 30%. Conclusion P. aeruginosa causes increased infections,mainly lung infections,showing an increasing detection rate year by year and a growing drug resistance,and the monitoring of drug resistance should be strengthened.
出处
《安徽医学》
2016年第7期794-797,共4页
Anhui Medical Journal
基金
铜陵市卫计委资助项目(卫科研[2014]31号)
关键词
铜绿假单胞菌
抗菌药物
耐药性
Pseudomonas aeruginosa
Antimicrobial agents
Drug resistance
