摘要
格林-巴利综合征（GBS）又称急性炎性脱髓鞘性多发性神经炎,是神经系统由体液和细胞免疫共同介导的单向性自身免疫性周围神经病.临床特点为双侧对称性、弛缓性肢体瘫痪、腱反射消失、面瘫及周围性感觉障碍.多发性硬化（MS）是中枢神经系统一种与免疫有关的脱髓鞘疾病,临床表现为视觉及眼球运动障碍,肢体感觉异常,肌肉无力、痉挛,排尿功能障碍及轻度的认知功能障碍.GBS和MS的病因尚不完全清楚,二者同属脱髓鞘病,发病机制及治疗均有相似之处.
Guillain-Barre syndrome （GBS） is an acute inflammatory Polyradiculoneuropathy.It is oneway autoimmune peripheral neuropathy caused by the cellular and humoral immune.The hallmark features of GBS are bilateral,symmetric and flaccid acroparalysis and ascending weakness with reduced deep tendon reflexes.It also caused facial paralysis and peripheral nerve sensory disturbance.Multiple sclerosis is a demyelinative and autoimmune disease of central nervous system.The clinical manifestation includes dysfunction of visual sense and ocular movement,limb paraesthesia,muscle weakness,spasm,urinate dysfunction,and mild recognition impairment of which the typical is featured by multiple nervous lesion.The pathogenesis of Guillain-Barre＆#39;syndrome（GBS） and multiple sclerosis （MS）is incompletely understood,but they all belong to demyelinating diseases.There are similarities in pathogenesis and treatment.This article aims to review the similarities and differences in pathogenesis and treatment of Guillain-Barre syndrome and multiple sclerosis.
出处
《国际免疫学杂志》
CAS
2016年第4期392-395,405,共5页
International Journal of Immunology
