摘要
目的探讨血清铁蛋白与冠心病的关系。方法采用病例对照研究设计（冠心病患者和健康对照各256例）,利用问卷调查收集研究对象的基本情况,测量血压、体重、身高、腰围、臀围。采集空腹静脉血检测血脂、血糖、血清铁蛋白等指标。采用SPSS20.0进行统计分析,通过Logistic回归模型分析血清铁蛋白与冠心病的关系。结果年龄和性别在冠心病组和对照组的差异均无统计学意义（P〉0.05）,冠心病组的体质指数、腰臀比、甘油三酯、C反应蛋白、铁蛋白、收缩压、舒张压均明显高于对照组（P〈0.05）。单因素分析结果显示,体质指数、腰围、收缩压、甘油三酯、吸烟、饮酒、铁蛋白是冠心病的危险因素,在未扣除混杂因素的影响下血清铁蛋白第三分位组患冠心病的危险是第一分位组的12.30倍（95%CI：7.33~20.64）。在多因素Logistic回归模型中,校正了冠心病的危险因素影响后,血清铁蛋白与冠心病仍有关联,在模型1中血清铁蛋白最高水平组患冠心病的危险是最低水平组的13.75倍（95%CI：8.02~23.56）,在模型2中血清铁蛋白最高水平组患冠心病的危险是最低水平组的7.09倍（95%CI：3.68~13.64）。结论血清铁蛋白的升高与冠心病风险增加有关联。
Aim To investigate the relationship between serum ferritin and coronary heart disease（ CHD）.Methods 256 CHD patients and 256 healthy controls were recruited in our case-control study. Basic information was obtained by using questionnaire and measured for blood pressure,weight,height,waist circumference,hip circumference.Venous blood was collected for detecting serum lipid,fasting plasma glucose and ferritin. All data were analyzed with SPSS 20.0. Multivariate Logistic regression model was used to assess association of serum ferritin with coronary heart disease. Results There was no significant difference for gender and age between patients and controls（ P0.05）. The patients＇ body mass index（ BMI）,ratio of waist to hip circumference,triglyceride,C-reaction protein,serum ferritin,systolic blood pressure,and diastolic blood pressure were significantly higher than that of the controls（ P 0. 05）. Data from univariate analysis showed that BMI,waist circumference,systolic blood pressure,triglyceride,smoking,drinking and serum ferritin were risk factors of CHD. The highest group of serum ferritin had a 12.30-fold risk of CHD（ 95% CI：7.33 ~ 20.64） than the lowest group without adjustment for confounding factors. In multivariate Logistic regression model,after adjustment for traditional CHD risk factors,serum ferritin was still associated with CHD. The highest group of serum ferritin had a 13.75-fold risk of CHD（ 95% CI： 8. 02 ~ 23. 56） in model 1,and 7. 09-fold risk of CHD（ 95% CI： 3. 68 ~13.64） compared with the lowest group. Conclusion The study confirmed that high serum ferritin was associated with the increased risk of CHD.
出处
《中国动脉硬化杂志》
CAS
北大核心
2016年第8期833-836,共4页
Chinese Journal of Arteriosclerosis
基金
国家自然科学基金项目(81130052)
关键词
冠心病
血清铁蛋白
病例对照研究
Coronary Heart Disease
Serum Ferritin
Case-control Study
