摘要
目的对常用药物阿托伐他汀钙所致的药品不良反应（ADR）进行调查分析,为临床应用提供参考。方法采用样本分析方法,收集2013年10月至2015年6月心血管内科服用阿托伐他汀钙的1 000份病历,统计分析患者年龄、性别、基础疾病、合并用药对ADR的影响。结果阿托伐他汀所致的ADR主要为肝转氨酶异常,占样本量的1.6%,50~70岁之间患者发生率高,男性多于女性,合并用药是导致ADR发生的危险因素之一。结论阿托伐他汀钙在应用过程中安全性高,ADR可控。
Objective To summarize the adverse reaction of atorvastatin and provide reference for its clinical application.Methods 1 000 cases from October 2013 to June 2015 in our hospital were selected.And the sample analysis method was used to analyze the influence of the age,gender,underlying diseases and the combined medication on ADR.Results The adverse reactions of atorvastatin were mainly liver damage,accounting for 1.6%,and higher in patients aged 50 ~ 70,men more than women,durg combination was one of the risk factors lead to ADR.Conclusion The safety of atorvastatin calcium is high,and the adverse reactions of liver damage is reversible,and could be widely used in clinic.
出处
《吉林医药学院学报》
2016年第4期251-254,共4页
Journal of Jilin Medical University
关键词
阿托伐他汀
不良反应
样本分析
合理用药
atorvastatin
adverse reaction
sample analysis
rational use of drug
