摘要
目的分析全程护理干预对自体DC/CIK细胞维持治疗的肺腺癌患者的临床疗效。方法 选择2014年4月~2015年6月我院呼吸内科接诊的60例自体DC/CIK细胞治疗的肺腺癌患者作为研究对象。按照随机法将患者分为观察组和对照组,各30例。对照组在维持治疗后给予常规护理干预,观察组在对照组常规护理干预的基础上给予全程护理干预。复查患者肝肾功能,比较两组护理前后肝、肾功能检测指标变化、临床疗效及护理满意度。结果 两组患者护理干预后,ALT、AST水平均降低,对照组TBIL水平降低,观察组TBIL水平下降。护理后两组患者的肝功能检测差异具有统计学意义（P〈0.05）。护理后,两组患者Cys C、SCr、CCr肾功能检测指标变化差异有统计学意义（P〈0.05）。观察组患者总缓解率为83.33%,明显高于对照组的36.67%,两组患者临床疗效差异有统计学意义（P〈0.05）。对照组总满意率为63.33%,观察组总满意率为90.00%,两组患者护理满意度差异有统计学意义（P〈0.05）。结论 全程护理干预自体DC/CIK细胞治疗的肺腺癌患者后,患者肝肾功能影响小,临床疗效显著,取得较高护理满意度,该种护理模式值得在临床广泛应用推广。
Objective To analyze the clinical curative effects of whole course nursing intervention on autologous DC/ CIK cells maintenance therapy for patients with lung adenocarcinoma. Methods 60 patients with lung adenocarcinoma treated with autologous DC/CIK cells who were admitted to the Department of Respiratory Medicine in our hospital from April 2014 to June 2015 were selected as research subjects. The patients were evenly assigned to the observation group and the control group according to the randomization method, with 30 patients in each group. The control group was given regular nursing intervention after maintenance therapy, and the observation group was given whole course nursing intervention on the basis of regular nursing intervention. Patient＇s liver and kidney functions were re-examined. Changes of test indicators of liver and kidney functions, clinical effects and nursing satisfaction degree before and after nursing were compared between the two groups. Results After nursing intervention in the two groups of patients, the levels of ALT and AST both decreased. The TBIL level was decreased in the control group, and the TBIL level was re- duced in the observation group. There was statistical difference of liver function between the two groups of patients after nursing （P〈O.05）. After nursing, the difference of changes of indicators of liver function CsyC, SCr, CCr was significant （P〈0.05）. The overall remission rate in the observation group was 83.33%, significantly higher than that of 36.67% in the control group. The difference of clinical effects between the two groups was significant （P〈0.05）. The overall satis- faction grate in the control group was 63.33%, and the overall satisfaction rate in the observation group was 90.00%. The difference of satisfaction rate between the two groups was significant （P〈0.05）. Conclusion After comprehensive nursing intervention for patients with lung adenocarcinoma treated by autologous DC/CIK cells maintenance therapy the effects on liver and ki
出处
《中国现代医生》
2016年第15期150-153,共4页
China Modern Doctor
基金
浙江省医药卫生平台计划(2015DTA016)
关键词
免疫治疗
DC/CIK细胞
肺腺癌
肝肾功能
全程护理干预
Immunotherapy
DC/CIK cells
Lung adenocarcinoma
Liver and kidney function
Whole course nursing intervention
