摘要
目的分析失代偿期肝硬化住院患者营养不良现状及其与预后的关系。方法选取郑州市中医院2013年1月-2014年12月失代偿期肝硬化患者共101例。通过营养风险筛查2002(NRS2002)将其分为营养不良风险组和非营养不良风险组。对比两组患者血清营养指标、人体测量指标、人体成分、6个月内并发症发生率和病死率。计量资料组间比较采用t检验,计数资料组间比较采用χ2检验。结果营养不良风险组的白蛋白、总胆固醇、甘油三酯、血红蛋白、BMI、上臂肌围、肱三头肌皮褶厚度和握力显著低于非营养不良风险组,差异有统计学意义(t值分别为12.562、5.967、4.024、14.775、4.607、7.182、7.424、2.256,P值均<0.05)。营养不良风险组的细胞内液、总体液量、蛋白质、脂肪和骨骼肌肉含量显著低于非营养不良风险组,差异均有统计学意义(t值分别为2.920、6.152、1.713、2.444、1.693,P值均<0.05),浮肿指数显著高于非营养不良风险组(t=1.998,P<0.05)。营养不良风险组的6个月内的消化道出血、肝性脑病、门静脉血栓形成、电解质紊乱发生率和病死率显著高于非营养不良风险组(χ2值分别为6.410、4.436、3.978、4.316、7.285,P值均<0.05)。结论营养不良的失代偿期肝硬化患者,其并发症发生率和病死率显著升高,有必要在肝硬化早期加强营养状况筛查。
Objective To investigate the current status of malnutrition and its association with prognosis in hospitalized patients with decom- pensated liver cin＇hosis. Methods A total of 101 patients with decompensated liver cirrhosis who were treated in our department fi＇om Janu- ary 2013 to December 2014 were enrolled, and according to the Nutritional Risk Screening 2002, they were divided into malnutrition risk group and non - malnutrition risk group. Serum nutritional indices, anthropometric parameters, body composition, and the incidence rates of complications and fatality within 6 months were compared between the two groups. The t - test was used for comparison of continuous data between groups, and the ehi - square test was used for comparison of categorical data between groups. Results Compared with the non - malnutrition risk group, the malnutrition risk group had significantly lower serum levels of albumin, total cholesterol, triglyceride, and hemo- globin, body mass index, arm muscle circumference, triceps skinfold thickness, and grip strength （t = 12. 562, 5. 967, 4. 024, 14. 775, 4. 607, 7.182, 7. 424, and 2. 256, all P 〈 0.05 ）. Compared with the non - malnutrition risk group, the malnutrition risk group had signifi- cantly lower intraceUular water, total body water （TBW）, protein, fa~, and skeletal muscle content （t = 2. 920, 6. 152, 1.713, 2. 444, and 1. 693, all P 〈 0.05）, as well as a significantly higher extracellular water/TBW ratio （ t = 1. 998, P 〈 0. 05 ）. Compared with the non - malnutrition risk group, the malnutrition risk group had significantly higher incidence rates of gastrointestinal bleeding, hepatic encephalopa- thy, portal vein thrombosis, and electrolyte disturbance and fatality （X2 = 6. 410, 4. 436, 3. 978,4. 316, and 7. 285, all P 〈 0.05 ）. Con- clusion Patients with decompensated liver cirrhosis and malnutrition have significantly increased incidence rates of complications and fatali- ty, and it is necessary to enhance nutrition screening in the early st
出处
《临床肝胆病杂志》
CAS
2016年第6期1100-1103,共4页
Journal of Clinical Hepatology
基金
郑州市2014年科技计划(20140523)
关键词
肝硬化
营养不良
预后
liver cirrhosis
malnutrition
prognosis
