摘要
目的:研究蒙古扁桃药材石油醚提取物对高脂血症大鼠血脂水平的影响。方法:采用高脂饲料饲养5周建立高脂模型,将60只实验大鼠分成空白对照组、高脂模型组、血脂康组(61.7 mg·kg^(-1))、以及蒙古扁桃石油醚低、中、高剂量组(1 500、2 000、2 500 mg·kg^(-1)),给药7周后,眼底静脉丛取血,检测总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、低密度脂蛋白胆固醇(low density lipoprotein-C,LDL-C)、高密度脂蛋白胆固醇(high density lipoprotein-C,HDL-C),并计算血脂综合指数和动脉粥样硬化指数。结果:与高脂模型组比较,蒙古扁桃石油醚低剂量组大鼠血清中TC和LDL-C含量显著降低;血脂综合指数TC/HDL-C、LDL-C/HDL-C和动脉粥样硬化指数(atherosclerotic index,AI)的比值显著降低。结论:蒙古扁桃石油醚提取物有效调节血脂水平,同时降低发生心血管疾病的危险性。
Objective：To study the effect of the petroleum ether extract from Amygdalus mongolica on blood lipid level in hyperlipidemia rats. Methods：Model was established by feeding high-fat diet for five weeks. Experimental animals were divided into six groups：control group,model group,XUE Zhi-kang group（61.7 mg·kg^-1）and 1 000,2 000,2 500 mg·kg^-1 of the petroleum ether extract from Amygdalus mongolica. Hyperlipidemic indicators were tested after 7 weeks oral administration of petroleum ether extract. Lipid comprehensive index and atherosclerosis index were calculated. Results：Compared with the hyperlipidemic model group,low-dose group of petroleum ether extract group from Amygdalus mongolica could significantly decreased the level of serum TC、LDL-C in the hyperlipidemia rat and TC/HDL-C、LDL-C/HDL-C、atherosclerotic index（P〈0.01,P〈0.05）. Conclusion：Petroleum ether extract from Amygdalus mongolica could improve blood lipid level,reduced the risk of arteriosclerosis.
出处
《神经药理学报》
2015年第3期12-16,共5页
Acta Neuropharmacologica
基金
国家自然科学基金(No.81102760)
内蒙古自治区高等学校青年科技英才支持计划(No.NJYT-15-B01)
关键词
蒙古扁桃
石油醚提取物
高脂血症
Amygdalus mongolica
petroleum ether extract
hyperlipidemia
