摘要
目的探讨2型糖尿病患者下肢血管病变与血尿酸（BUA）水平的关系。方法收集2013年7月~2014年7月我院2型糖尿病患者384例,按照有无下肢血管病变将其分为实验组（有下肢血管病变,76例）和对照组（无下肢血管病变,308例）,对照组常规口服药或胰岛素治疗糖尿病,实验组在对照组基础上应用前列地尔注射液改善下肢血管病变。比较两组BUA水平差异,Spearman检验BUA水平和其他临床指标的相关关系,Logistic回归分析BUA水平与2型糖尿病患者下肢血管病变发生的相关因素。结果实验组BUA水平明显高于对照组,差异有统计学意义（P〈0.05）。Spearman检验结果显示,BUA水平与糖尿病患者体质量指数、收缩压、舒张压、总胆固醇（TC）、三酰甘油（TG）等呈正相关,与高密度脂蛋白胆固醇呈负相关（P〈0.05）。Logistic多因素回归分析结果显示,BUA、TC、TG、C反应蛋白与2型糖尿病患者下肢血管病变独立相关（P〈0.05）。结论 BUA水平与2型糖尿病患者下肢血管病变密切相关,是下肢血管病变发生的危险因素,针对糖尿病治疗的同时应严格控制BUA水平。
Objective To explore the relationship between lower extremity vascular disease and serum uric acid level of type 2 diabetic patients.Methods 384 type 2 diabetic patients from July 2013 to July 2014 of our hospital were selected.Patients were divided into experimental group（with lower extremity vascular disease,76 cases） and control group（without lower extremity vascular disease,308 cases）.Patients in control group were given routine oral drug or insulin,and patients in experimental group were given alprostadil injection to improve lower extremity vascular disease on the basis of control group.The difference of blood uric acid level in two groups was compared.The relationship between blood uric acid level and other clinical index was tested by Spearman test.The related factors between blood uric acid level and lower extremity vascular disease of type 2 diabetic patients was analyzed by Logistic regression analysis.Results The blood uric acid level in experimental group was obvious higher than that of control group with statistical difference（P〈0.05）.The Spearman test results showed that blood uric acid level had positive relationship with BMI,SBP,DBP,TC and TG of type 2 diabetic patients,while had negative relationship with HDL-C（P〈0.05）.Logistic regression analysis results showed that blood uric acid,TC,TG and CRP were dependent related with lower extremity vascular disease of type 2 diabetic patients（P〈0.05）.Conclusion Blood uric acid level has close relationship with lower extremity vascular disease of type 2 diabetic patients,which is the risk factor of occur of lower extremity vascular disease.In the treatment of diabetes,the level of blood uric acid should be strictly controlled.
出处
《中国当代医药》
2016年第17期35-37,共3页
China Modern Medicine
基金
广东省阳江市卫生计生局科技计划项目(阳卫计2014004)
关键词
2型糖尿病
下肢血管病变
血尿酸
Type 2 diabetic
Lower extremity vascular disease
Blood uric acid
