摘要
目的分析卵巢非侵袭性低级别浆液性癌（low-grade serous carcinoma,LGSC）患者保留生育功能手术的特点。方法回顾性收集2015年1月至2015年6月北京协和医院病理诊断为卵巢非侵袭性LGSC且进行保留生育功能手术的患者,对其临床病理特点、手术过程和随访情况进行总结。结果共有5例非侵袭性LGSC且保留生育功能患者,中位年龄29岁（24~34岁）;1例行开腹手术,4例行腹腔镜手术;4例手术行卵巢囊肿剔除,1例患者因为卵巢急性扭转坏死行受累附件切除。1例国际妇产科联盟（International Federation of Gynecology and Obstetrics,FIGO）分期为IB期,4例为IA期。所有患者术后均未接受进一步治疗。中位随访7个月（6~12个月）,所有患者均未复发,1例患者自然受孕且母胎情况良好。结论对于非侵袭性LGSC患者,能否保留生育功能、保留生育功能手术术后的生育情况、复发率及随诊方案,仍是目前临床处理的棘手问题。本研究为年轻的非侵袭性LGSC患者提供了保留卵巢的选择,但患者的长期预后（包括生育和生存）尚有待进一步随访。
Objective To investigate the characteristics of fertility-sparing surgery for non-invasive low-grade serous carcinoma （ LGSC） of the ovary .Methods All the histologically diagnosed patients of non-inva-sive LGSC who admitted to Peking Union Medical College Hospital and received fertility -sparing surgeries between January 2015 and June 2015 were reviewed and their clinicopathological characteristics , surgical procedures , and follow-up results were retrospectively analyzed .Results Totally five cases of non-invasive LGSC receiving fertili-ty-sparing surgeries were reviewed .Their median age was 29 years （range, 24-34 years）.One case received laparotomy and four received laparoscopies; four cases received ovarian cystectomy and one received emergency unilateral adnexectomy for the affected and necrotic ovary because of acute torsion .One case was diagnosed at In-ternational Federation of Gynecology and Obstetrics （ FIGO） stage IB, and the other four were at stage IA .All the five cases received no further therapy after the surgery .The median follow-up period was 7 months （ range , 6-12 months ） .No case relapsed so far .One case conceived naturally and both the mother and the fetus were in＆amp;nbsp;good condition .Conclusions For non-invasive LGSC patients , there are many unresolved issues in aspects of spare of fertility , conception after fertility-sparing surgeries , recurrence , and follow-up.Although the possibility to spare the ovary is supported by this study for young non-invasive LGSC patients , long-term prognosis （ inclu-ding fertility and survival ） needs to be observed in further follow-up.
出处
《协和医学杂志》
2016年第4期285-289,共5页
Medical Journal of Peking Union Medical College Hospital
