摘要
目的:探讨乳腺癌术后化疗对骨质密度变化的影响及(99)~锝-亚甲基双膦酸盐的治疗作用。方法:观察58例乳腺癌术后化疗患者化疗期间骨质密度、血钙素(BGP)、碱性磷酸酶(AKP)、24h尿钙水平变化。化疗结束后,将其中23例骨质疏松症患者分为对照组和观察组,对照组给予碳酸钙D3,观察组在对照组基础上加用(99)~锝-亚甲基双膦酸盐,治疗1年后比较两组患者骨质密度、BGP、AKP、24h尿钙水平变化。结果:化疗患者腰椎骨密度、股骨骨密度较化疗前显著降低,BGP、AKP、24 h尿钙则较前显著升高(P<0.05)。乳腺癌术后化疗3个疗程后骨质疏松症发生率为22.4%,化疗6个疗程后骨质疏松症发生率为39.7%。观察组患者腰椎骨密度、股骨骨密度较治疗前显著升高,BGP、AKP、24 h尿钙则显著降低;且两组比较,差异有统计学意义(P<0.05)。结论:乳腺癌术后化疗可导致骨质密度降低,使用(99)~锝-亚甲基双膦酸盐治疗乳腺癌术后化疗所致骨质疏松症安全有效。
Objective： To evaluate the effect of postoperative chemotherapy on bone density change in the patients with breast cancer and the therapeutic effect of 99 TC-MDP.Methods： Totally 58 breast cancer patients with postoperative chemotherapy were se-lected, and the changes of bone density , blood calcium element （BGP）, alkaline phosphatase （ALP） and 24 h urinary calcium levels were observed .After the chemotherapy , the osteoporosis patients were divided into the control group and the observation group , and the control group was given calcium carbonate D 3, while the observation group was given calcium carbonate D 3 combined with 99 TC-MDP. The bone density , BGP, ALP and 24 h urinary calcium levels were compared between the two groups .Results：After the chemothera-py, the bone mineral density of lumbar vertebra and thighbone was decreased significantly , BGP, ALP and 24 h urine Ca were in-creased significantly, and compared with those before the treatment , the differences were statistically significant （P〈0.05）.After the 3-course postoperative chemotherapy , the incidence of osteoporosis was 22.4%（13/58）, and after the six-course chemotherapy, the incidence of osteoporosis was 39.7%（23/58）.The bone mineral density of lumbar vertebra and thighbone in the observation group was increased significantly , BGP, ALP and 24 h urine Ca were decreased significantly , and compared with those in the control group , the differences were statistically significant （P〈0.05）.Conclusion： Postoperative chemotherapy for breast cancer can lead to reduced bone density , and 99 TC-MDP in the treatment of osteoporosis induced by breast cancer postoperative chemotherapy is safe and effective .
出处
《中国药师》
CAS
2016年第7期1328-1330,共3页
China Pharmacist
基金
丽水市科技局科研基金资助项目(编号:2010JYZB23)
