摘要
采用硅胶、ODS柱色谱和制备型HPLC等色谱技术从尖叶假龙胆乙醇提取物中分离得到12个酮类成分,经MS和NMR等波谱技术分别鉴定为1,7-二羟基-3-甲氧基酮-7-O-β-D-吡喃葡萄糖苷（1）,紫药苷（2）,1,3,8-三羟基-4,5-二甲氧基酮-1-O-β-D-吡喃葡萄糖基（6→1）-O-β-D-吡喃葡萄糖苷（3）,1,2,8-三羟基-5,6-二甲氧基酮-2-O-β-D-吡喃葡萄糖苷（4）,1,3,7,8-四羟基酮-1-O-β-D-吡喃葡萄糖苷（5）,1,3,5,8-四羟基-5,6,7,8-四羟基酮（6）,1,3,5-三羟基酮（7）,1,3,5,8-四羟基酮（8）,1,2,8-三羟基-5,6-二甲氧基酮（9）,雏菊叶龙胆酮（10）,芒果苷（11）,当药醇苷（12）。化合物1~9均为首次从假龙胆属中分离得到。
Twelve xanthones compounds were isolated from the ethanol extract of Gentianella acuta by means of reversed-phase preparative HPLC and various kinds of column chromatography including silica gel and ODS. Their structures were fully elucidated on the basis of MS,1D and 2D-NMR data. The structures of xanthones were identified as 1,7-dihydroxy-3-methoxyxanthone-7-O-β-D-glucopyranoside（ 1）,swertiapuniside（ 2）,1,3,8- trihydroxy-4,5-dimethoxyxanthone-1-O-β-D-glucopyranosyl（ 6→1）-O-β-D-glucopyranoside（ 3）,1,2,8-trihydroxy-5,6-dimethoxyxanthone-2-O-β-D-glucopyranoside（ 4）,1,3,7,8-tetrahydroxyxanthone-1-O-β-Dglucopyranoside（ 5）,1,3,5,8-tetrahydroxy-5,6,7,8-tetrahydroxanthone（ 6）,1,3,5-thihydroxyxanthone（ 7）,1,3,5,8-tetrahydroxyxanthone（ 8）,1,2,8-trihydroxy-5,6-dimethoxyxanthone（ 9）,bellidifolin（ 10）,mangiferin（ 11）,swertianolin（ 12）.Compounds 1-9 were isolated from Gentianella genus for the first time.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2016年第12期2280-2283,共4页
China Journal of Chinese Materia Medica
基金
国家重点基础研究发展计划(973)计划项目(2013CB531801)
教育部博士点基金项目(20132327120002)
黑龙江中医药大学"优秀创新人才"支持项目(2012RCD05)
黑龙江中医药大学"杰出人才培养"基金项目(2012cj02)
关键词
尖叶假龙胆
酮类
结构鉴定
Gentianella acuta
xanthones
structure identification
