摘要
利用多种色谱分离方法对金樱子根中的化学成分进行分离和纯化,并根据化合物的理化性质和光谱分析进行结构鉴定。从金樱子根的乙酸乙酯及丙酮提取部位中分离得到了12个三萜类化学成分,分别鉴定为：（2R,19R）methyl 2-acetyloxy-19-hydroxyl-3-oxo-urs-12-en-28-carboxylate（1）、坡模酮酸（2）、18,19-seco,2α,3α-dihydroxy-19-oxo-urs-11,13（18）-dien-28-oic acid（3）、swinhoeic acid（4）、千花木酸（5）、2α,3β,19α-trihydroxy-24-oxo-urs-12-en-oic acid（6）、委陵菜酸（7）、阿江榄仁尼酸（8）、1β-羟基蔷薇酸（9）、quadranosideⅧ（10）、高山地榆苷（11）、rubuside B（12）。其中,化合物1~4,6,9,11~12为首次从金樱子中分离得到;化合物2~4,6,11~12为首次从蔷薇属分离得到。
To study the triterpenoids from the roots of Rosa laevigata. The silica gel column chromatography was used to separate the chemical constituents from the roots of Rosa laevigata Michx. HPLC was used to analyze its purity,chemical and spectroscopy methods were used to determine their structures. 12 constituents were isolated and identified as（ 2R,19R） methyl 2-acetyloxy-19- hydroxyl-3-oxo-urs-12-en-28-carboxylate（ 1）,pomonic acid（ 2）,18,19-seco,2α,3α-dihydroxy-19-oxo-urs-11,13（ 18）-dien-28-oic acid（ 3）,swinhoeic acid（ 4）,myrianthic acid（ 5）,2α,3β,19α-trihydroxy-24-oxo-urs-12-en-oic acid（ 6）,tormentic acid（ 7）,arjunic acid（ 8）,1β-hydroxyeuscaphic acid（ 9）,quadranoside Ⅷ（ 10）,alpinoside（ 11）,rubuside B（ 12）. Compounds 1-4,6,9,11-12 were obtained from this plant for the first time. Compounds 2-4,6,11-12 were obtained from the genus Rosa for the first time.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2016年第12期2267-2272,共6页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(81360683)
关键词
金樱子
化学成分
三萜类
千花木酸
高山地榆苷
Rosa laevigata
chemical compositions
triterpenoid
myrianthic acid
alpinoside
