摘要
目的分析抗心磷脂抗体（ACA）及抗β2糖蛋白Ⅰ（β2-GPI）抗体的滴度值对妊高病患者妊娠结局的影响。方法选取冠县人民医院2013年9月至2015年9月收治的120例妊娠高血压患者作为观察组,按照病情轻重将60例轻度子痫前期患者作为观察组A,将60例重度子痫前期患者作为观察组B,另选择同时期收治的正常分娩产妇60例作为对照组,采用ELISA法对三组产妇的血清抗心磷脂抗体及抗β2-GP1抗体的滴度值进行检测,并对比三组患者的妊娠结局。结果观察组B较观察组A、对照组相比,ACA-Ig G、ACA-Ig M及抗β-GPI抗体水平升高,差异具有统计学意义（t=3.45~6.89,均P〈0.05）。观察组A与对照组相比,胎儿生长受限、早产、围生儿死亡、胎盘早剥、死胎发生率明显增加,差异具有统计学意义（χ2=4.45~7.12,均P〈0.05）。观察组B较观察组A、对照组相比胎儿生长受限、早产、围生儿死亡、胎盘早剥、死胎发生率明显增加,差异具有统计学意义（χ2=4.92~7.34,均P〈0.05）。ACA-Ig M与胎儿生长受限有显著相关性（r=0.42,P〈0.05）。ACA-Ig G及抗β-GPI抗体水平与早产发生率呈显著相关性,随着抗体水平的升高,早产发生率也相应增高（r值分别为0.54、0.68,均P〈0.05）。ACA-Ig G、ACA-Ig M及抗β-GPI抗体水平3者之间两两存在显著的相关性（r值分别为0.619、0.616、0.382,均P〈0.05）。结论血清抗心磷脂抗体及抗β2-GPI抗体可能均参加了子痫前期的发生发展过程,子痫前期患者不良妊娠结局率较高,早期检测ACA及β2-GPI抗体的滴度值具有好的应用价值。
Objective To explore and analyze the effects of titers of anticardiolipin antibodies（ ACA） and anti-β2 glycoprotein I antibodies（ anti-β2-GPI） on the pregnancy outcomes of patients with pregnancy induced hypertension（ PIH）. Methods A total of 120 cases of patients with PIH were selected in observation group. All these patients received treatments at People＇s Hospital of Guan County from September 2013 to September 2015. In accordance with disease severity,60 patients with mild preeclampsia were selected in observation group A,while the rest patients with severe preeclampsia in observation group B. Moreover,another 60 puerperae who delivered their babies naturally at the same period were chosen in control group. Titers of serum ACA and anti-β2-GPI of puerperae in three groups were detected with the aid of ELISA method. Besides,pregnancy outcomes of three groups were compared. Results Compared with observation group A and the control group,observation group B had higher levels of ACA-Ig G,ACA-Ig M and anti-β-GPI. The preceding difference was statistically significant（ t = 3. 45- 6. 89,all P〈0. 05）. Puerperae in observation group A had significantly higher incidence rate of fetal growth restriction,premature delivery,perinatal mortality,placental abruption and stillbirth. The difference was of statistical significance（ χ2= 4. 45- 7. 12,all P〈0. 05）. There was significant correlation between ACA-Ig M and fetal growth restriction（ r = 0. 42,P〈0. 05）.Besides,obvious correlation was witnessed between levels of ACA-Ig G and anti-β-GPI. The incidence rate of premature delivery increased with incvease of antibodies levels（ r value was 0. 54 and 0. 68 respectively,both P〈0. 05）. In addition,significant correlations existed between each two factors among levels of ACA-Ig G,ACA-Ig M and anti-β-GPI antibodies（ r value was 0. 619,0. 616 and 0. 382,respectively,all P〈0. 05）. Conclusion It is possible that both serum ACA and anti-β2-GPI antibodies have participated in the onset
出处
《中国妇幼健康研究》
2016年第6期768-770,共3页
Chinese Journal of Woman and Child Health Research
关键词
妊娠高血压
子痫前期
血清抗心磷脂抗体
抗β2-GPI抗体
pregnancy induced hypertension（PIH）
preeclampsia
anticardiolipin antibody（ACA）
anti-β2 glycoprotein I antibody（anti-β2-GPI）
