摘要
探讨适度运动对冠心病患者生活质量及冠脉侧支循环建立的作用,阐明其康复治疗的重要意义,并探讨其可能机制。根据随访结果选择84例经冠脉造影示前降支100%闭塞的单支病变患者。所有患者均于入选前、入选1年后行冠状动脉造影检查,并在入选后1年检测血管内皮生长因子(VEGF)及儿茶酚胺抑素(CST)水平。规范药物治疗+适度运动组侧支循环建立和开放率最高。规范药物治疗+适度运动组侧支循环建立和开放率高于规范药物治疗组,差异有统计学意义。不论是否用药,适度运动者VEGF、CST水平高于未运动者,VEGF、CST水平与是否规范用药无关。适度运动可以增加冠脉闭塞病变患者的侧支循环开通机会,其机制可能与适度运动增加VEGF和CST水平有关。
This paper is to explore the impact of moderate exercise on the quality of life in patients with coronary artery occlusion and the establishment of the coronary collateral circulation.The authors clarified the significance of moderate exercise in the rehabilitation therapy in patients with coronary artery occlusion and discuss possible mechanism.According to the inclusion criteria,we investigated 84 patients with coronary angiogram show left anterior descending arteries 100% occlusion of coronary artery after 1year.After 1year,the patients were divided into four group based on follow-up study.All patients with coronary angiography undergone examination to observe collateral circulation before selected,as well as 1year after.The venous blood was collected to detect VEGF and CST level after 1year.The authors compared with the opening and establishment of collateral circulation,the people who insisted on standardized medication and moderate exercise had the highest rate.People just insisted on standardized medication and moderate exercise higher than just standardized medication,the difference had statistically significance.Regardless of whether the drugs,moderate exerciser＇s VEGF and CST levels higher than not exerciser VEGF and CST level has nothing to do with whether standard medication.Moderate exercise can increase the chances of collateral circulation opening.Maybe moderate exercise can increase the level of VEGF and CST.
出处
《医学与哲学（B）》
2016年第5期33-35,85,共4页
Medicine & Philosophy(B)
基金
2014年度辽宁省教育厅资助项目
项目编号:30456023
关键词
冠心病
适度运动
侧支循环
coronary heart disease
moderate exercise
collateral circulation
