摘要
背景与目的:结外NK/T细胞淋巴瘤(extranodal natural killer/T-cell lymphoma,ENKTL)为非霍奇金淋巴瘤的一个亚型,中国发病率远高于西方国家。该病恶性程度高,对化疗不敏感,生存期短,预后差,EB病毒(Epstein-Barr virus,EBV)感染与该病的发生、发展有密切关系,但仍有少数患者无EBV感染。本研究探讨EBV编码的小m RNA(EBV-encoded small RNA,EBER)原位杂交阴性患者的临床特征及预后相关因素。方法:选取2011年8月—2015年10月郑州大学第一附属医院病理科诊断为ENKTL的326例标本,采用原位杂交技术检测其EBER表达,回顾性分析8例EBER阴性患者临床特征及预后相关因素。结果:326例ENKTL中,EBER表达阴性率为2.45%(8/326),8例EBER表达阴性患者的中位生存期为17个月。EBER阴性与EBER阳性患者的生存率log-rank检验,两条生存曲线差异有统计学意义(χ2=6.407,P=0.011)。多变量Cox比例风险回归分析表明,乳酸脱氢酶(lactate dehydrogenase,LDH)与EBER阴性ENKTL患者预后有关(P=0.008),血浆中EBV-DNA拷贝数与EBER阴性患者的预后无关(P>0.05)。结论:EBER表达阴性ENKTL发病率低,预后较EBER阳性患者差,LDH升高可能是其预后不良因素。
Background and purpose： Extranodal natural killer/T-cell lymphoma （ENKTL） is a form of non-Hodgkin＇s lymphoma. The ENt（TL incidence in China is much higher than that in the Western countries. The disease is highly malignant, not sensitive to chemotherapy, has short survival period and poor prognosis. Epstein-Barr virus （EBV） infection has close relationship with the development of the disease. However, there are still a few patients without EBV infection. This study aimed to discuss the clinical features and prognosis of EBV-encoded small RNA （EBER） in situ hybridization negative ENKTL. Methods： From Aug. 2011 to Oct. 2015, 326 cases were diagnosed with ENKTL from the First Affiliated Hospital of Zhengzhou University. The expression of EBER was detected by in situ hy- bridization technique. The clinical pathological characteristics and prognosis of EBER-negative patients were analyzed. Results： In 326 patients with ENKTL, the negative rate of EBER was 2.45% （8/326）. In 8 EBER-negative patients, the median survival time was 17 months. The log-rank test revealed that there was a significant difference between EBER-negative and EBER-positive curves （χ2=6.407, P=0.011）. Multivariate Cox nronortional hazards regression analysis showed that in EBER-negative ENKTL, only lactate dehydrogenase （LDH） predicted survival time （P=-0.008）. EBV-DNA copy number in plasma was not significantly correlated with survival time （P〉0.05）. Conclusion： The inci- dence of EBER-negative ENKTL is low. Patients with EBER-negative ENKTL have poorer prognosis than EBER-posi- tive patients. Elevated LDH may be a factor indicating poor prognosis.
出处
《中国癌症杂志》
CAS
CSCD
北大核心
2016年第6期533-537,共5页
China Oncology
基金
河南省科技计划项目(142300410389)
