摘要
目的:探讨胺碘酮联合美托洛尔治疗慢性心力衰竭(chronic heart failure,CHF)合并室性心律失常(ventricular arrhythmia,VA)的临床疗效。方法:选择2012年3月—2015年3月81例CHF合并VA患者,按随机数字表法分为观察组和对照组。观察组40例患者给予胺碘酮联合美托洛尔进行治疗,对照组41例患者给予胺碘酮单药治疗,观察2组患者心功能、VA变化情况、再住院及心脏事件发生情况,并比较2组患者的不良反应发生情况。结果:治疗6个月后,在VA治疗方面,观察组患者的总有效率为92.50%(37/40),明显高于对照组的75.61%(31/41),差异有统计学意义(P<0.05);在心功能改善方面,观察组患者的总有效率为85.00%(34/40),明显高于对照组的65.85%(27/41),差异有统计学意义(P<0.05);观察组患者再住院率和心脏事件发生率明显低于对照组,差异均有统计学意义(P<0.05);2组患者不良反应发生率的差异无统计学意义(P>0.05)。结论:胺碘酮联合美托洛尔治疗CHF合并VA疗效较好,安全性较高,值得临床推广。
OBJECTIVE：To probe into the clinical efficacy of amiodarone combined with metoprolol in treatment of chronic heart failure（CHF） with ventricular arrhythmias（VA）.METHODS： 81 patients with CHF and VA admittedfrom Mar.2012 to Mar.2015 were selected to be divided into observation group and control group via the randomnumber table.40 cases in the observation group were treated with amiodarone combined with metoprolol , while41 cases in the control group received amiodarone.The cardiac function changes of VA, readmission and cardiac eventof two groups were observed; and the adverse drug reactions were compared between two groups .RESULTS： Aftertreatment of 6 months, as for VA, the total effective rate of observation group was 92.50%（37/40）, significantlyhigher than that of control group [75.61%（31/41）], with statistically significant difference （P 〈0.05）.As forcardiac functionm, the total effective rate of observation group was 85.00%（34/40）, significantly higher than that ofcontrol group [65.85%（27/41）], with statistically significant difference （P 〈0.05）.The incidence of readmissionand cardiac event in observation group were significantly lower than that of control group , with statistically significantdifference（P 〈0.05）.There were no significant difference between two groups in incidence of adverse drug reactions（P〉0.05）.CONCLUSIONS： The efficacy of amiodarone combined with metoprolol in treatment of CHF with VA isremarkable, with high safety.It is worthy of clinical application and promotion .
出处
《中国医院用药评价与分析》
2016年第6期746-748,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
