摘要
目的探讨心肌梗死患者经皮冠状动脉介入（PCI）术后小剂量氯吡格雷延长治疗的临床效果。方法选取2011年1月～2013年10月我院收治的100例心肌梗死患者为研究对象,均采用PCI术治疗,采用随机数字表法将其分为观察组和对照组,各50例。患者PCI术后延续抗血小板用药1年,对照组患者单纯给予阿司匹林口服治疗,观察组患者采用阿司匹林联合小剂量氯吡格雷治疗,随访1年,观察比较两组患者的心脑血管事件发生率及不良反应发生率。结果观察组患者总体心脑血管事件的发生率显著低于对照组,且在非致死性再发梗死、再发心绞痛及脑梗死方面显著低于对照组,差异有统计学意义（P〈0.05）;观察组患者的胃肠道反应发生率低于对照组（P〈0.05）,两组白细胞减少、血小板减少、出血的发生率比较,差异无统计学意义（P〉0.05）。结论心肌梗死患者PCI术后小剂量氯吡格雷延长应用能有效降低主要心脑血管事件发生率,且不明显增加胃肠道反应的发生,未增加出血及血小板减少等用药风险,值得在临床上推广和应用。
Objective To investigate the clinical effect of low dose clopidogrel in patients with myocardial infarction after PCI.Methods 100 patients with myocardial infarction who treated with PCI in our hospital from January 2011 to October 2013 were selected as research objects.They were divided into the observation group and the control group by using the method of random number table,each of 50 cases.Patients with PCI continued anti platelet drug use for 1year.The control group treated with oral aspirin therapy,patients in the observation group used aspirin combined with low dose of clopidogrel therapy,patients were followed up for 1 year,the incidence of cardiovascular events and incidence of adverse events were observed and compared between the two groups.Results Incidence of cardiovascular events in observation group was significantly lower than that of the control group and in the non lethal recurrent infarction,recurrent angina pectoris and infarction also was significantly lower than that of control group,with statistical difference（P 〈0.05）.The incidence of gastrointestinal reactions in the observation group was lower than that in the control group（P〈0.05）;the incidence of the white blood cells,thrombocytopenia and bleeding between two groups had not statistically significant（P〉0.05）.Conclusion After PCI in patients with myocardial infarction clopidogrel extended application can effectively reduce the incidence of major cardiovascular time and no obvious increase in the incidence of gastrointestinal reaction,does not increase bleeding and thrombocytopenia drug risk,it is worth popularizing and applying in clinic.
出处
《中国当代医药》
2016年第16期131-133,共3页
China Modern Medicine
关键词
心肌梗死
经皮冠状动脉介入
阿司匹林
氯吡格雷
心脑血管事件
Myocardial infarction
Percutaneous coronary intervention
Aspirin
Clopidogrel
Cardiovascular and cerebrovascular events
