摘要
目的观察去氨加压素联合护理干预治疗高龄男性夜尿症的效果和安全性。方法选取2014年6月-2015年5月在解放军总医院门诊诊断为夜尿症的74例高龄男性患者,将其随机分为去氨加压素治疗联合护理干预组（A组,25例）、去氨加压素治疗组（B组,25例）和安慰剂对照组（C组,24例）。A、B组睡前口服0.1-0.2 mg去氨加压素片,A组同时接受护理干预治疗,C组睡前口服安慰剂,疗程共3周。比较三组治疗前后夜间尿量、夜间排尿次数、夜间多尿指数、第1次觉醒时间,以及肾功能、凝血功能、血钠浓度变化。结果与C组比较,治疗后A、B两组患者夜间尿量、夜间排尿次数和夜间多尿指数均显著减少,第1次觉醒时间显著延长,差异均有高度统计学意义（P〈0.01）。治疗后,A组患者夜间尿量、夜间排尿次数均少于B组,差异有统计学意义（P〈0.05）。A、B两组治疗后夜间尿量、夜间多尿指数和第1次觉醒时间均较治疗前明显改善,差异有高度统计学意义（P〈0.01）。A组治疗后夜间排尿次数较治疗前明显减少,差异有高度统计学意义（P〈0.01）,B、C组夜间排尿次数治疗前后比较差异无统计学意义（P〉0.05）。三组治疗前后肾功能（尿素氮、肌酐）和凝血功能指标（凝血酶原时间、凝血酶时间、活化部分凝血活酶时间和纤维蛋白原）变化比较差异均无统计学意义（P〉0.05）。三组治疗前后血钠水平均在正常范围内,但A组有4例患者、B组有3例患者治疗后血钠〈130 mmol/L。结论去氨加压素联合护理干预能有效治疗高龄患者夜尿症,可以明显减少夜间尿量和夜尿排尿次数。
Objective To observe the effects and safety of desmopressin combined with nursing intervention in the treatment of elderly male patients with nocturia. Methods Seventy four cases of elderly male patients diagnosed as nocturia in Outpatient Department of Chinese PLA General Hospital from June 2014 to May 2015 were selected and randomly divided into desmopressin combined with nursing intervention group（group A）, desmopressin treatment group（group B, 25 cases） and placebo group（group C, 24 cases）. Group A and B were given 0.1-0.2 mg desmopressin orally before sleep, group A received nursing intervention at the same time, group C received placebo orally before sleep, the course was 3 weeks. The nocturnal urine volume, times of nocturnal urine, nocturnal polyuria index, first awakening time, and the changes of renal function, coagulation function, serum natrium levels before and after treatment among the three groups were compared. Results Compared with group C, the nocturnal urine volume, times of nocturnal urine and nocturnal polyuria index in group A, B after treatment were reduced, the first awakening time was lengthened, the differences were highly statistically significant（P〈0.01）. After treatment, the nocturnal urine volume, times of nocturnal urine of group A were all less than those of group B, the differences were statistically significant（P〈0.05）. The nocturnal urine volume, nocturnal polyuria index and first awakening time in group A, B after treatment were all improved compared with those before treatment, the differences were highly statistically significant（P〉0.01）. The times of nocturnal urine of group A after treatment were reduced compared with that before treatment, the difference was highly statistically significant（P〈0.01）, the times of nocturnal urine in group B, C before and after treatment had no statisticallysignificant differences（P〈0.05）. The changes of renal function（blood urea nitrogen, creatinine）, coagulation function（prothrombin time, thro
出处
《中国医药导报》
CAS
2016年第17期132-136,共5页
China Medical Herald
基金
解放军总医院临床科研扶持基金项目(2015FCTSYS-1019)
关键词
去氨加压素
护理干预
高龄
男性
夜尿症
Desmopressin
Nursing intervention
Elderly
Male
Nocturia
