摘要
虽然成年哺乳动物的心脏具备有限的再生能力,但在心肌损伤后无法弥补丢失的心肌细胞.运动诱导心脏再生,不仅能促进心肌细胞的肥大和自我更新、抑制凋亡,而且能影响血管内皮细胞和成纤维细胞的功能.IGF-1/PI3K/Akt信号通路、C/EBPβ/CITED4转录因子、一氧化氮是运动促进心脏再生的重要分子机制.微小RNA作为生物学标记物,在运动诱导的心脏再生中的作用日益受到关注.更重要的是,运动诱导的心脏再生对心肌梗死、心肌缺血再灌注损伤、代谢型心肌病、衰老相关的心肌损伤具有保护效应.基于运动诱导的心脏再生将成为治疗心血管疾病的新途径.
Adult mammalian heart has limited regenerative capacity, obviously insufficient to recover cardiomyocyte loss after injury. Exercise can induce cardiac regenera- tion, not only through promoting cardiomyocyte hypertrophy and renewal while reducing apoptosis, but also through modulating the functions of endothelial cells and fibroblasts. IGF-1/PI3K/Akt signaling, C/EBPβ/CITED4 transcription factors and nitric oxide are essential molecular mechanisms mediating exercise-induced cardiac regeneration. In addition increasing interests are focused on the roles of microRNAs, considered as important biomarkers, in exercise-induced cardiac regeneration. More importantly, exercise-induced cardiac regeneration protects against myocardial infarction, ischemia-reperfusion injury, metabolic cardiomyopathy, and aging-related myocardial injury. Exercise-induced cardiac regeneration may be a potential therapeutic strategy for cardiovascular diseases.
出处
《上海大学学报（自然科学版）》
CAS
CSCD
北大核心
2016年第3期293-301,共9页
Journal of Shanghai University:Natural Science Edition
基金
国家自然科学基金资助项目(81570362)
国家自然科学青年基金资助项目(81400647)
关键词
心脏再生
运动
心肌细胞
干细胞
cardiac regeneration
exercise
cardiomyocyte
stem cell
