摘要
目的比较康复新液与浓替硝唑含漱液对低危妊娠滋养细胞肿瘤MTX化疗性口腔溃疡的临床疗效。方法我院2013年12月至2015年12月收治的低危滋养细胞肿瘤患者,选取50例合并口腔溃疡患者作为研究对象,分为2组,每组25例。治疗组:给予康复新溶液,对照组给予浓替硝唑含漱液,评价两组疗效和毒副反应。结果康复新液组治疗有效率为96%,浓替硝唑组为80%,两组比较差异有统计学意义(P<0.05)。口腔溃疡的愈合情况比较:治疗组愈合时间为(4.3±1.9)d;对照组为(7.1±2.6)d,两组比较差异有统计学意义(P<0.05)。所有患者均未发生与康复新液和浓替硝唑相关的不良反应。结论康复新液治疗低危妊娠滋养细胞肿瘤患者相关化疗性口腔溃疡安全有效,值得临床推广。
Objective To compare the effect of Kangfuxin solution and tinidazole on oral ulcer induced by MTX chemotherapy of patients with gestational trophoblastic neoplasia（GTN）.Methods Fifty patients with GTN complicated with oral ulcer were randomly divided into Kangfuxin solution group（n= 25） and tinidazole group（n=25）.The curative efficacy of the two groups was compared.Results The total effective rate in Kangfuxin solution group was higher than that of tinidazole group（96%vs.80%）,there being significant difference between the two groups（P〈 0.05）.The average healing time in Kangfuxin solution group was shorter than that of tinidazole group：（4.3 ± 1.9） d vs.（7.1 ± 2.6） d,there being significant difference between the two groups（P〈0.05）.No obvious adverse reaction occurred in the two groups.Conclusion The efficacy of Kangfuxin solution in the treatment of oral ulcer induced by MTX chemotherapy is better than tinidazole,it is worthy of wide application.
出处
《实用药物与临床》
CAS
2016年第6期688-691,共4页
Practical Pharmacy and Clinical Remedies
