摘要
目的探讨桂枝茯苓胶囊对缺血缺氧耐受力的影响。方法按体质量将小鼠随机分为空白对照组、阳性药物对照组(普萘洛尔)、桂枝茯苓胶囊大剂量组(0.93g/kg)、桂枝茯苓胶囊小剂量组(0.465g/kg),连续给药7d,采用密闭缺氧实验、断头致脑缺氧实验、亚硝酸钠致脑缺氧实验以及异丙肾上腺素致脑缺氧实验,记录小鼠耐缺氧存活时间;建立异丙肾上腺素致大鼠心肌缺血缺氧模型,并以桂枝茯苓胶囊进行治疗,探讨其对缺血缺氧的影响。结果与空白对照组相比,大剂量桂枝茯苓胶囊对密闭导致的缺氧存活时间和大、小剂量桂枝茯苓胶囊对断头致脑缺氧存活时间有延长趋势(P>0.05);小剂量桂枝茯苓胶囊对亚硝酸钠导致的缺氧存活时间、大剂量桂枝茯苓胶囊对异丙肾上腺素导致的缺氧存活时间具有显著延长作用(P<0.05)。与模型对照组相比,大、小剂量桂枝茯苓胶囊对异丙肾上腺素致大鼠心肌缺血缺氧坏死面积有显著降低作用(P<0.05)。结论桂枝茯苓胶囊对异丙肾上腺素导致的大鼠心肌缺血缺氧具有显著的保护作用。
Objective To investigate the protective effect of Gui Zhi Fuling Jiaonang on endurance to ischemia and hypoxia .Methods Mice were randomized into four groups ：control group ,positive drug control group ,Gui Zhi Fuling Jiaonang high‐dose group （0 .93 g/kg） ,and Gui Zhi Fuling Jiaonang low‐dose group （0 .465 g/kg） . All mice were treated with corresponding drugs for 7 days .The hypoxia mice model was established through hypoxia in the closed jars , cerebral anoxia by decapitation , poisoning with sodium nitrite and isoprenaline . Then the hypoxia‐ischemia rat model was established by injecting isoproterenol . The anti‐hypoxic effects were observed . Results Compared with control group ,Gui Zhi Fuling Jiaonang high‐dose group （0 .93 g/kg） had a tendency to extend the survival time of mice model established through hypoxia in the closed jars ;Gui Zhi Fuling Jiaonang high‐dose （0 .93 g/kg） and low‐dose （0 .465 g/kg） groups had a tendency to extend the survival time of mice model established through cerebral anoxia by decapitation （P〉0 .05） .Compared with that in control group ,the survival time of mice in Gui Zhi Fuling Jiaonang low‐dose group under poisoning with sodium nitrite and Gui Zhi Fuling Jiaonang high‐dose group under poisoning with isoprenaline were significantly prolonged .Besides ,Gui Zhi Fuling Jiaonang relieved myocardial tissue damage caused by ischemia and hypoxia （ P〈 0 .05 ） .Conclusion Gui Zhi Fuling Jiaonang has an obviously protective effect on isoprenaline‐induced hypoxia and myocardial ischemia .
出处
《西安交通大学学报（医学版）》
CAS
CSCD
北大核心
2016年第4期590-593,603,共5页
Journal of Xi’an Jiaotong University（Medical Sciences）
基金
四川省科技厅基本科研项目~~
关键词
桂枝茯苓胶囊
心肌缺氧
心肌缺血
Gui Zhi Fuling Jiaonang
myocardial anoxia
myocardial ischemia
