摘要
胃肠道生产20多种肽类激素。其中,胰高血糖素样肽1(GLP-1)在过去的30年里受到最多关注。人们对GLP-1以及另一肠道激素葡萄糖依赖性促胰岛素肽(GIP)功能的研究已导致了两类新的糖尿病治疗药物的开发,分别称为GLP-1R激动剂和DPP-Ⅳ抑制剂。肠道的这些内分泌细胞不是聚集在内分泌腺体中,而是广泛分布在整个胃肠道中,从而与"外部"环境包括食物以及肠道菌群充分接触。本文简要介绍了GLP-1以及营养成分如何调节其分泌,并重点讨论了肠道环境如何影响GLP-1的产生和分泌,包括肠道菌群的贡献。
There are more than two dozens of peptide hormones that are produced and released from the gastrointestinal （GI） tract. Among them, the incretin hormone glucagon-like peptide 1 （GLP-1） has received the most intensive attention for the past 30 years. Functional studies on GLP-1 and anoth- er gut incretin hormone glucose-dependent insulinotropic peptide （GIP） have led to the development of novel diabetes therapeutic agents known as GLP-1 receptor agonists and DPP-VI inhibitors. Instead of forming endocrine glands, the gut hormone producing endocrine cells are widely spread throughout the entire GI tract, permitting vital interactions with the ＂external＂ environment. Here a brief introduction on GLP-1 and how nutritional components regulate its secretion were made, followed by reviewing some key development on how gut environment affects the production and secretion of GLP-1, including the contribution of gut microbiota.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
2016年第6期691-702,608,共12页
Chinese Journal of Pharmacology and Toxicology
基金
the Canadian Diabetes Association and Canadian Institutes of Health Research for supporting his GLP 1 related research
