摘要
Smad4作为转化生长因子(TGF)-β信号通路中的细胞内信使,越来越受到关注。众多研究发现,Smad4在女性生殖系统恶性肿瘤中起着抑癌基因的作用。Smad4蛋白在肿瘤中表达降低或缺失,可促进肿瘤发生、发展。Smad4与女性生殖系统恶性肿瘤患者的低生存率及不良预后关系密切。随着研究的深入,Smad4有望成为女性生殖系统恶性肿瘤有价值的诊断与预后评估标志物,以及治疗靶点。笔者拟就Smad4与女性生殖系统恶性肿瘤关系的研究进展进行综述如下。
Smad4,one of the intracellular messengers of transforming growth factor（TGF）-βsignaling pathway,has been paid more and more attention.Lots of studies have proved that Smad4 plays the role of tumor suppressor gene in malignant tumor of female reproductive system.The reduced or deleted expression of Smad4 protein in those tumor tissues can promote the occurence and development of carcinoma.Smad4 is also associated with low survival and poor prognosis of patients with malignant tumor of female reproductive system.With further research,Smad4 may be a valuable marker of diagnosis and evaluation of the prognosis and target of malignancy treatment in malignant tumor of female reproductive system.This review will summarize the research progress of relations between Smad4 and malignant tumor of female reproductive system.
出处
《中华妇幼临床医学杂志（电子版）》
CAS
2016年第3期349-353,共5页
Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)
基金
国家卫计委公益性行业科研专项项目(201402010)~~
