摘要
目的:了解某院念珠菌血流感染的菌群分布和耐药情况,为临床合理用药提供依据。方法:对蚌埠医学院第一附属医院2010-2014年血培养结果为念珠菌的资料进行回顾性分析。结果:19 245份血培养标本中检出病原菌2 237株,其中念珠菌76株,检出率3.4%。76株念珠菌中白色念珠菌最多,占51.3%(39/76),其次为光滑念珠菌18.4%(14/76),近平滑念珠菌15.8%(12/76)。主要分布在ICU 14.5%(11/76),血液科11.8%(9/76)等。76株念珠菌对两性霉素B和5-氟胞嘧啶最为敏感,敏感率均为97.4%,伏立康唑的敏感率为96.1%,氟康唑和伊曲康唑的敏感率分别为90.8%和88.2%。结论:血培养分离的念珠菌以白色念珠菌最多,念珠菌对两性霉素B和5-氟胞嘧啶保持较高敏感性,对氟康唑、依曲康唑敏感性有所下降。
Objective：To investigate the pathogen distribution and drug resistance of Candida bloodstream infection to provide the basis for clinical rational drug use. Methods：The data of Candida infection isolated from blood culture were retrospectively analyzed in the First Affiliated Hospital of Bengbu Medical College from 2010 to 2014. Results：The 2 237 stains pathogenic bacteria were isolated from 19 245 blood culture specimens,which included 76 strains Candida,and the detection rate was 3. 4%. Among the 76 strains Candida,the detect rates of Candida albicans,C. glabrata and C. parapsilosis were 51. 3%（39/76）,18. 4%（14/76） and 15. 8% （12/76）,respectively,and the patients mainly came from the ICU（14. 5%,11/76）,and the department of Hematology（11. 8%,9/76）. The 76 strains Candida were the highest sensitivity to amphotericin B and flucytosine,the sensitive rate of which was 97. 4%. The sensitivity rate of 76 strains Candida to voriconazole,fluconazole and itraconazole were 96. 1%m,90. 8% and 88. 2%,respectively. Conclusions：The main pathogen of Candida isolated from bloodstream infection was Candida albicans. The sensitivities of Candida to amphotericin B and flucytosine are the highest,and the sensitive rate of Candida to fluconazole and itraconazole begin to decrease.
出处
《蚌埠医学院学报》
CAS
2016年第5期661-663,共3页
Journal of Bengbu Medical College
关键词
念珠菌
血培养
药物敏感性试验
Candida
blood culture
antibacterial susceptibility test
