摘要
目的：探讨阿昔洛韦＋醋酸泼尼松片、丙氧鸟苷＋醋酸泼尼松片＋阿司匹林两种给药方案治疗急性视网膜坏死综合征的临床疗效。方法：采用随机数字表法将我院急性视网膜坏死综合征患者30例40眼分为A、B两组,其中A组采用阿昔洛韦＋醋酸泼尼松片的给药方案,B组采用丙氧鸟苷＋醋酸泼尼松片＋阿司匹林的给药方案,观察并比较两组患者治疗后的临床效果。结果：经过治疗后,B组总有效率（90%）明显高于A组（70%）,两种给药方案均有效,差异无统计学意义（P〉0.05）;两组患者在治疗前视力情况差异无统计学意义（P〉0.05）;经不同给药方案治疗后,A组视力≥0.5者9眼,视力0.1-〈0.5者3眼,视力0.02-〈0.1者6眼,无感光者2眼,B组视力≥0.5者12眼,视力0.1-〈0.5者4眼,视力0.02-〈0.1者3眼,无感光者1眼,B组患者视力恢复情况优于A组,差异有统计学意义（P〈0.05）;B组患者视网膜裂孔、疱疹、口腔溃疡、水痘、病毒性脑炎及中枢神经病变等并发症的发生率（10%）明显低于A组（35%）,差异有统计学意义（P〈0.05）。结论：阿昔洛韦＋醋酸泼尼松片、丙氧鸟苷＋醋酸泼尼松片＋阿司匹林两种给药方案都具有较为肯定的治疗效果,但后者对患者视力的恢复及并发症发生率的降低具有更好的优势。
AIM： To investigate clinical efficacy of two drug therapies （ acyclovir with prednisone acetate tablets, ganciclovir with prednisone acetate tablets and aspirin） for acute retinal necrosis syndrome. METHODS： Thirty patients （40 eyes） with acute retinal necrosis syndrome in our hospital were randomly divided into group A and B. Group A was treated with acyclovir with prednisone acetate tablets, and group B was given ganciclovir with prednisone acetate tablets and aspirin. Clinical effects in the two groups were observed and compared. RESULTS： After treatment, the overall response rate in group B （90%） was obviously higher than that in group A （70%）, both of two regimens were effective, without significant difference （P〉0. 05）. There was no significant difference on the pre - treatment visual acuity between the two groups （P〉0. 05）. After different treatments, the visual acuity in group B was ≥0. 5 in 12 eyes, 0. 1≤and〈0. 5 in 4 eyes, 0. 02 ≤ and 〈 0. 1 in 3 eyes, and no photosensitive in 1 eye. The visual acuity in group A was≥0. 5 in 9 eyes, 0. 1≤and〈0. 5 in 3 eyes, 0. 02≤and〈0. 1 in 6 eyes, and no photosensitive in 2 eyes. The recovery of visual acuity in group B was obviously better than that in A group （ P 〈 0. 05）. The incidence of complications such as retinal tear, herpes, mouth ulcers, chickenpox, viral encephalitis and central nervous system diseases in group B （10%） was significantly lower than that in A group （35%,P〈0. 05）. CONCLUSION： Two drug therapies （ acyclovir with prednisone acetate tablets, ganciclovir with prednisone acetate tablets and aspirin ） both have positive therapeutic effect, but the latter can better restore visual acuity and decrease the complications.
出处
《国际眼科杂志》
CAS
2016年第7期1366-1368,共3页
International Eye Science
