摘要
目的:调查广西陆川县婚检人群地中海贫血携带率,分析婚检筛查地中海贫血的方法及临床意义。方法:选取陆川县2014年1月-2015年1月进行婚检筛查地中海贫血的男女共18 276例,进行血常规检测,并对MCV、MCH、RDW检测结果进行分析。结果:18 276例婚检人群中,检测出地中海贫血表型阳性者4068例,占22.3%,其中夫妇双阳者500例。单独使用MCV或MCH筛查的敏感度低于联合筛查,差异均有统计学意义(P<0.05);单独用MCH筛查结果优于单独用MCV筛查结果,差异有统计学意义(P<0.05)。结论:陆川县地中海贫血携带者较多,应用MCV、MCH联合的方法进行筛查能够提高敏感度。加强婚前医学检查,从而发现地中海贫血携带双阳的夫妇,通过进一步的地中海贫血基因检测和产前诊断,降低地中海贫血出生缺陷的发生率。
Objective：To investigate the carrying rate of thalassemia in premarital examination in Luchuan County of Guangxi,to analyze the methods and clinical significance of premarital screening of thalassemia.Method：18 276 cases of premarital examination population in Luchuan County from January 2014 to January 2015 were selected,they were given routine blood test,and the detection results of MCV,MCH,RDW were analyzed.Result：Among the 18 276 cases of premarital examination population,4068 cases were detected thalassemia phenotype positive,accounting for 22.3%,which including 500 cases of couples who were both positive.The sensitivity of MCV or MCH screening alone was lower than that of united screening,the differences were statistically significant（P〈0.05）.The sensitivity of MCH screening alone was better than that of MCV screening alone,the difference was statistically significant（P〈0.05）.Conclusion：The carrier of thalassemia in Luchuan County is more,the MCV,MCH joint screening method can improve the sensitivity.Strengthening the premarital medical examination can help find the couple both carrying thalassemia.Through detection and prenatal diagnosis of thalassemia gene further to reduce the incidence of birth defects.
出处
《中外医学研究》
2016年第18期63-64,共2页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
地中海贫血
婚检人群
携带率
调查
Thalassemia
Premarital population
Carrying rate
Survey
