摘要
目的探讨还原型谷胱甘肽对老年糖尿病患者药物性肝损伤（DILI）的临床疗效。方法选取我院2012年1月-2014年12月收治的老年糖尿病合并DILI患者62例,将其随机分成治疗组与对照组,每组31例。对照组予常规治疗,治疗组在对照组基础上应用还原型谷胱甘肽注射液1.2 g,加入生理盐水150 ml静脉滴注,1次/d,连用6周,比较两组患者的治愈率及不良反应发生率。结果治疗组患者的治愈率为87.1%,高于对照组的64.5%,差异有统计学意义（P〈0.05）。两组患者不良反应发生率比较,差异无统计学意义（P〉0.05）。结论还原型谷胱甘肽能提高老年糖尿病DILI的治愈率,降低患者转为慢性肝病率。
Objective To explore the clinical effects of reduced glutathione in diabetes drug induced liver injury in the elderly patients. Methods 62 elderly diabetes patients with drug induced liver injury from January 2012 to December2014 of our hospital were selected and were randomly divided into treatment group and control group.Each group was31 cases.Patients in control group were given routine treatment,and patients in treatment group were given intravenous infusion reduced glutathione injection 1.2 g into saline 150 ml once a day,for 6 weeks on the basis of control group.The cure rate and incidence of adverse reaction between two groups were compared. Results The cure rate in treatment group was 87.1%,higher than 64.5% in control group with statistical difference（P〈0.05）.The incidence of adverse reactions between the two groups had no statistical differenc（P〉0.05）. Conclusion Reduced glutathione can enhance the cure rate and decrease the rate of turn into chronic liver disease of elderly diabetes patients with drug induced liver injury.
出处
《中国当代医药》
2016年第15期29-31,共3页
China Modern Medicine
