摘要
目的探讨32P敷贴联合普萘洛尔治疗儿童大面积皮肤毛细血管瘤的临床疗效。方法将45例大面积毛细血管瘤患儿分为两组,进行前瞻性研究。对照组20例,其中≤3岁儿童草莓状血管瘤10例、>3岁儿童鲜红斑痣10例,接受常规32P敷贴治疗。观察组25例,其中≤3岁儿童草莓状血管瘤10例、>3岁儿童鲜红斑痣15例,接受32P敷贴联合普萘洛尔治疗。对比两组不同类型血管瘤、≤3岁儿童与>3岁儿童的治疗效果及不良反应。统计计数资料采用χ2检验和零反应检验,以P<0.05为差异有统计学意义。结果对照组与观察组总有效率分别为80.0%与88.0%(P>0.05);两治疗组中≤3岁儿童血管瘤有效率分别为90.0%与100.0%(P>0.05);但两治疗组中>3岁儿童鲜红斑痣有效率分别为40.0%与80.0%,差异有统计学意义(P<0.05)。对照组单用32P敷贴在≤3岁儿童与>3岁儿童有效率分别为90.0%与40.0%,差异有统计学意义(P<0.05),观察组用32P敷贴联合普萘洛尔在≤3岁儿童与>3岁儿童有效率分别为100.0%与80.0%,差异无统计学意义(P>0.05)。两组发生湿性皮炎分别为25.0%与40.0%,发生色素脱失分别为75.0%与84.0%,差异均无统计学意义(P>0.05);发生心率减慢在≤3岁儿童与>3岁儿童分别为50.0%与40.0%,差异无统计学意义(P>0.05)。结论32P敷贴联合普萘洛尔治疗难治性大面积血管瘤,治疗方法简单、安全,疗效较好。但要密切注意32P、普萘洛尔两者不良反应的发生及处理。
Objective To investigate the clinical efficacy of 32p applicator plus propranolol in children with a large area of skin capillary hemangioma. Methods Forty five cases of large hemangioma were divided into two groups. Control group of 20 patients recieved the conventional 32p application therapy. Of 20 cases in control group, there were 10 cases ≤3 years old children with hemangiomas, and 10 cases 〉 3 years old children with Port Wine Stain（ PWS ）. Observation group of 25 cases recieved 32p applicator plus propranolol. Of 25 cases in observation group 10 cases werer≤3 years old children with hemangiomas, 15 cases of children with PWS. Comparison was made between two different types of vascular tumors ,treatment in ≤3 years old children and 〉 3 years old children, and adverse reactions. Data statistical analysis used X2 test and zero reaction test. P 〈 0.05 was considered statistically significant. Results The treatment efficacy was 80.0% in control group and 88.0% in observation group（ P 〉 0.05 ）. The treatment efficacy in ≤3 years old children with infant hemangioma was 90.0% in control group and 100% in observation group （ P 〉 0.05 ）. The treatment efficacy for PWS in 〉 3 years old children was 40.0% in control group and 80% in observation group. Here the difference is statistically significant（P 〈0.05）. When compared ≤3 years old children with 〉 3 years old children in control group, the treatment efficacy was 90. 0% and 40. 0%, respectively （P 〈 0.05 ）. When compared≤ 3 years old children with 〉 3 years old children in observation group, the treatment efficacy was 100.0% and 80.0% with no significant difference（P 〉 0.05 ）. Complication of moist dermatitis was 25.0% in control group and 40.0% in observation group. Occurrence of depigmentation was 75.0% and 84.0% in control and observation group with no significant difference（P 〉 0.05 ）. Changing in heart rate occurs in ≤3 years old children and 〉 3 years old children,50.0% and 40.0%, respective
出处
《标记免疫分析与临床》
CAS
2016年第6期685-687,712,共4页
Labeled Immunoassays and Clinical Medicine
