摘要
目的:通过乳酸清除率及SOFA评分的变化,观察血必净注射液对综合ICU脓毒症休克患者的治疗效果。方法:选取脓毒症休克患者80例,随机分为常规治疗组(以下简称A组)和血必净组(以下简称B组),A组确诊脓毒症休克后采用常规集束化治疗方案,B组在集束化治疗基础上增加血必净注射液100 ml静脉滴注每12小时一次,疗程7 d。观察两组治疗前以及开始治疗6 h、12 h、24 h的动脉血乳酸值,分别计算并比较乳酸清除率。计算两组确诊时、治疗过程中及治疗7 d后的SOFA评分,分别比较两组治疗前后及最高SOFA评分(治疗过程中的最高值)。结果:A组治疗前、治疗6h、12 h、24 h的乳酸水平分别为(5.70±1.41)mmol/L、(3.83±1.16)mmol/L、(2.42±0.82)mmol/L、(1.65±0.65)mmol/L,其6 h、12 h、24 h的乳酸清除率分别为(33.18±14.05)%、(58.01±9.90)%、(71.31±8.64)%,其治疗前、治疗后的SOFA评分及治疗过程中的最高SOFA评分分别为(8.78±2.95)分、(6.97±2.88)分、(12.22±2.94)分;B组治疗前、治疗6h、12 h、24 h的乳酸水平分别为(5.73±1.19)mmol/L、(3.54±1.00)mmol/L、(2.00±0.76)mmol/L、(0.98±0.37)mmol/L,其6 h、12 h、24 h的乳酸清除率分别为(38.91±10.87)%、(65.62±9.84)%、(82.81±5.42)%,其治疗前、治疗后的SOFA评分及治疗过程中的最高SOFA评分分别为(8.95±3.25)分、(3.95±2.50)分、(10.45±3.09)分。两组患者治疗后的动脉血乳酸水平及SOFA评分均有改善,其中B组乳酸清除率显著高于A组,差异有统计学意义(P<0.05),治疗后的SOFA评分及治疗中最高值显著低于A组,差异有统计学意义(P<0.05)。结论:血必净注射液能够明显促进脓毒症休克患者的乳酸清除,改善脓毒症休克的预后。
Objective Observing the changes of lactate clearance rate and Sequential Organ Failure Assessment（ SOFA）,to assess the clinical curative effect of Xuebijing injection in treating septic shock patients. Method We selected 80 patients who were diagnosised as septic shock. The patients were randomly divided into the conventional treatment group（ A group） and the Xuebijing group（ B group）. The A group treated with bundle strategies,while B group was added with traditional Chinese medicine Xuebijing injection 100 ml intravenous driped every 12 hours for 7 days on the basis of bundle strategies. The levels of arterial blood lactate before treatment and in the sixth hour,the twelfth hour,the twenty- fourth hour will be observed,then count and compare the lactate clearance rates. At the same time,count the scores of Sequential Organ Failure Assessment before treatment,in the course of treatment and after seven days. Compare the scores before and after treatment period,and the maximum in the course of treatment. Results The levels of lactate before treatment and in the sixth hour,the twelfth hour,the twenty- fourth hour in A group were（ 5. 70 ±1. 41） mmol/L、（ 3. 83 ±1. 16） mmol/L、（ 2. 42 ±0. 82） mmol/L、（ 1. 65 ± 0. 65） mmol/L,respectively. The lactate clearance rates in the sixth hour,the twelfth hour,the twenty- fourth hour in A group were（ 33. 18 ± 14. 05） % 、（ 58. 01 ± 9. 90） % 、（ 71. 31± 8. 64） %,respectively. The scores before and after treatment period,and the maximum in the course of treatment in A group were（ 8. 78 ±2. 95） 、（ 6. 97 ± 2. 88） 、（ 12. 22 ± 2. 94）,respectively. The levels of lactate before treatment and in the sixth hour,the twelfth hour,the twenty- fourth hour in B group were（ 5. 73 ± 1. 19） mmol / L、（ 3. 54 ± 1. 00） mmol / L、（ 2. 00 ± 0. 76） mmol / L、（ 0. 98 ±0. 37） mmol/L,respectively. The lactate clearance rates in the sixth hour,the twelfth hour,the twenty- fourth hour in B group were（ 38. 91 ±
出处
《吉林医学》
CAS
2016年第6期1339-1342,共4页
Jilin Medical Journal
关键词
脓毒症休克
乳酸清除率
SOFA
血必净
Septic shock
Lactate clearance rate
SOFA
Xuebijing injection
