摘要
目的系统评价IL-4基因-589C/T多态性与COPD发病风险的相关性。方法计算机检索Pub Med、EMbase、CNKI和Wan Fang Data数据库,搜集IL-4基因-589C/T多态性与COPD相关性的病例-对照研究,检索时限截至2016年2月23日。由2位研究者独立筛选文献、提取资料和评价纳入研究的偏倚风险后,采用Rev Man5.3软件进行Meta分析。结果最终纳入8个病例-对照研究,共1 400例病例和1 073例对照。Meta分析结果显示,IL-4基因-589C/T多态性与COPD发病风险无相关性[TT+TC vs.CC:OR=0.84,95%CI(0.61,1.15),P=0.27;TT vs.CC+TC:OR=0.95,95%CI(0.72,1.25),P=0.69;TT vs.CC:OR=1.14,95%CI(0.74,1.76),P=0.55;TC vs.CC:OR=0.83,95%CI(0.66,1.05),P=0.12;T vs.C:OR=0.91,95%CI(0.72,1.14),P=0.40]。结论 IL-4基因-589C/T多态性可能不是COPD发病的危险因素。
Objective To systematically review the association between -589C/T polymorphism in IL-4 gene and the risk of chronic obstructive pulmonary disease （COPD）. Method PubMed, EMbase, CNKI and WanFang Data databases were electronically searched to identify case-control studies which investigated the association between IL-4 -589C/T polymorphism and the risk of COPD. The search date was up to February 23th, 2016. Two reviewers independently screened the studies, extracted data and assessed the risk of bias of included studies, and then meta-analysis was performed by using RevMan 5.3 software. Results A total of 8 case-control studies involving 1 400 COPD cases and 1 073 controls were included in meta-analysis. The results showed that： the -589C/T polymorphism in IL-4 gene was not associated with the risk of COPD （TT＋TC vs. CC： OR=0.84, 95%CI 0.61 to 1.15, P=0.27; TT vs. CC＋TC： OR=0.95, 95%CI 0.72 to 1.25, P=0.69; TT vs. CC： OR=1.14, 95%CI 0.74 to 1.76, P=0.55; TC vs. CC： OR=0.83, 95%CI 0.66 to 1.05, P=0.12; T vs. C： OR=0.91, 95%CI 0.72 to 1.14, P=0.40）. Conclusion The IL-4 -589C/T polyrnorphism is not associated with the risk of COPD.
出处
《中国循证医学杂志》
CSCD
2016年第6期663-667,共5页
Chinese Journal of Evidence-based Medicine
基金
成都市卫生局课题(编号:2015025)
